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Team:Imperial College/Modelling beta-amyloid
From 2013.igem.org
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<h2>Introduction</h2> | <h2>Introduction</h2> | ||
| - | <p align="justify"> This is another degradation model we designed to help UCL 2013 iGEM team with their Beta-Amyloid degradation assays. | + | <p align="justify"> This is another degradation model we designed to help UCL 2013 iGEM team with their Beta-Amyloid degradation assays. [href="https://2013.igem.org/Team:UCL/Project/Degradation| Beta-Amyloid Degradation Assays] Beta-Amyloid is known as the component of Amyloids Plaque in association with Alzheimer's disease, in which the target of UCL iGEM this year <a href="https://2013.igem.org/Team:UCL/Background/Alzheimers" target="_blank">Alzheimer's disease (AD)</a>. Matrix metallopeptidase 9 (MMP-9) was discovered to be able to degrade Beta-Amyloid that can be potentially used to cure Alzheimer's disease. The model provides information about how efficient is MMP-9 enzyme to degrade Beta-Amyloids base on the assays from UCL team.</p> |
<h2>Description</h2> | <h2>Description</h2> | ||
Revision as of 20:43, 30 September 2013
Contents |
Beta-Amyloid Degradation Model
Introduction
This is another degradation model we designed to help UCL 2013 iGEM team with their Beta-Amyloid degradation assays. [href="https://2013.igem.org/Team:UCL/Project/Degradation| Beta-Amyloid Degradation Assays] Beta-Amyloid is known as the component of Amyloids Plaque in association with Alzheimer's disease, in which the target of UCL iGEM this year <a href="https://2013.igem.org/Team:UCL/Background/Alzheimers" target="_blank">Alzheimer's disease (AD)</a>. Matrix metallopeptidase 9 (MMP-9) was discovered to be able to degrade Beta-Amyloid that can be potentially used to cure Alzheimer's disease. The model provides information about how efficient is MMP-9 enzyme to degrade Beta-Amyloids base on the assays from UCL team.
Description
Objective
The Mathematical model is based on MATLAB extension Simbiology, it will predict how long will take to degrade a certain concentration of Beta-Amyloid by a given amount of MMP-9 enzyme. The simulation results can help UCL iGEM team to modify their assays in order to achieve better experimental results. The model can also be used to provide a preliminary prediction of degrading Amyloid Plaque in vivo.
Degradation Assays of UCL 2013 iGEM team
