Team:Goettingen/Project

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===Target: c-di-AMP===
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<p>Since the discovery of penicillin by Alexander Fleming in 1928, antibiotics have marked a major victory of mankind in the battle against infectious diseases. However, after 90 years, the available antibiotics are losing their old time glory: Bacteria can rapidly acquire resistance against antibiotics and become unbridled.</p>
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<p>We should have better control over the use of antibiotics, meanwhile, we need to develop new ones, which can sufficiently eliminate the invaders without hurting the "good" bacteria. Therefore, c-di-AMP, a recently discovered signaling molecule that is <strong>essential</strong> in many pathogenic bacteria, has come to our sight.</p>
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*[[Team:Goettingen/Project/OurProject|Our Project]]
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<p>Our project is aimed at finding a way to fight against multi-resistant bacteria by targeting c-di-AMP. We made three different approaches, each approach was accomplished by a subteam, for detailed information, please click the icon on the right panel.</p>
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**[[Team:Goettingen/Team/Reporters|Reporter Team]]
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<p style="margin-left: 150px;text-indent: -125px;"><strong>Reporter Team: </strong>development of a reporter system to monitor c-di-AMP levels <i>in vivo</i></p>
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**[[Team:Goettingen/Team/Array|Array Team]]
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<p style="margin-left: 150px;text-indent: -100px;"><strong>Array Team: </strong>identification of regulatory elements that bind to c-di-AMP</p>
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**[[Team:Goettingen/Team/DAC|DAC Team]]
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"><strong>DAC Team: </strong>characterisation of a diadenylate cyclase that produces c-di-AMP.</p>
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<p>After over 3 month of work, we have finally wrapped up. To know more details about our lab work, please visit [[Team:Goettingen/NoteBook|Our Lab Book]].</p>
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<p>We conducted all experiments in a S1 level lab in the Department of General Microbiology that is located on the North Campus of the Göttingen University. We strickly stuck to the rules that have to be followed during work in a S1 lab. To know more about safety issues, please [[Team:Goettingen/Safety|visit our safety page]].
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        <h3>The lack of novel antibiotics: the problem that we address </h3>
 
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        <p>The discovery of penicillin by Alexander Fleming in 1928 and the broad application of antibiotics marked a major victory of mankind in the  battle against infectious diseases. </p>
 
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<p> However, shortly after the beginning of industrial  penicillin  production in 1942 some human  pathogens  already acquired resistance against penicillin and related antibiotics. </p>
 
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<p>Moreover, the frequent use of antibiotics in the past and the rapid adaptation of bacteria to  these compounds  led to the development  of many multi-resistant pathogens.  </p>
 
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<p>Some of the pathogenic  bacteria  are even resistant  against most commercially available antibiotics.  Therefore, both the discovery and the development of new antibacterial substances  are extremely important to fight these threats of human health. Unfortunately, the pipeline of novel compounds with antibiotic activity  and appropriate pharmaceutical properties is  empty. This makes the challenge of finding  new compounds even more urgent!</p>
 
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<p> The first step in designing efficient novel antibacterial  compounds is the identification  of a suitable target. Very recently, a potentially interesting  target has been identified. The emerging signaling molecule cyclic dinucleotide c-di-AMP is essential in the Gram-positive model organism  B. subtilis  and in closely related pathogenic bacteria  such as Listeria monocytogenes, Streptococcus pneumoniae, and Staphylococcus aureus. </p>
 
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<p> These bacteria cause serious diseases and are often multi-resistant. c-di-AMP is needed for  the control  of  vital cellular processes in these pathogens because both: lack and accumulation of c-di-AMP, strongly inhibit growth of the bacteria. </p>
 
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<p> Therefore, any substance that disturbs  the homeostasis of the important signaling molecule c-di-AMP and the interaction with its  target is of substantial interest to fight human pathogens. The next important step in identifying  efficient antibacterial compounds, which either inhibit c-di-AMP biosynthesis or interfere  with the essential function of c-di-AMP  in the cell, is the development of a powerful screening system. </p>
 
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Latest revision as of 13:24, 4 October 2013





The beast and its Achilles heel:

 A novel target to fight multi-resistant pathogenic bacteria


Target: c-di-AMP

Since the discovery of penicillin by Alexander Fleming in 1928, antibiotics have marked a major victory of mankind in the battle against infectious diseases. However, after 90 years, the available antibiotics are losing their old time glory: Bacteria can rapidly acquire resistance against antibiotics and become unbridled.

We should have better control over the use of antibiotics, meanwhile, we need to develop new ones, which can sufficiently eliminate the invaders without hurting the "good" bacteria. Therefore, c-di-AMP, a recently discovered signaling molecule that is essential in many pathogenic bacteria, has come to our sight.

Our project is aimed at finding a way to fight against multi-resistant bacteria by targeting c-di-AMP. We made three different approaches, each approach was accomplished by a subteam, for detailed information, please click the icon on the right panel.

Reporter Team: development of a reporter system to monitor c-di-AMP levels in vivo

Array Team: identification of regulatory elements that bind to c-di-AMP

DAC Team: characterisation of a diadenylate cyclase that produces c-di-AMP.

After over 3 month of work, we have finally wrapped up. To know more details about our lab work, please visit Our Lab Book.

We conducted all experiments in a S1 level lab in the Department of General Microbiology that is located on the North Campus of the Göttingen University. We strickly stuck to the rules that have to be followed during work in a S1 lab. To know more about safety issues, please visit our safety page.


Overview

Array Team

DAC Team

Reporter Team

Parts

Collaboration

Retrieved from "http://2013.igem.org/Team:Goettingen/Project"