Team:Goettingen/Project
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===Target: c-di-AMP=== | ===Target: c-di-AMP=== | ||
<p>Since the discovery of penicillin by Alexander Fleming in 1928, antibiotics have marked a major victory of mankind in the battle against infectious diseases. However, after 90 years, the available antibiotics are losing their old time glory: Bacteria can rapidly acquire resistance against antibiotics and become unbridled.</p> | <p>Since the discovery of penicillin by Alexander Fleming in 1928, antibiotics have marked a major victory of mankind in the battle against infectious diseases. However, after 90 years, the available antibiotics are losing their old time glory: Bacteria can rapidly acquire resistance against antibiotics and become unbridled.</p> | ||
- | <p>We should have better control over the use of antibiotics, meanwhile, we need to develop new ones, which can sufficiently eliminate the invaders without hurting the "good" bacteria. Therefore, c-di-AMP, a recently discovered signaling molecule that is <strong>essential</strong> in many pathogenic | + | <p>We should have better control over the use of antibiotics, meanwhile, we need to develop new ones, which can sufficiently eliminate the invaders without hurting the "good" bacteria. Therefore, c-di-AMP, a recently discovered signaling molecule that is <strong>essential</strong> in many pathogenic bacteria, has come to our sight.</p> |
<p>Our project is aimed at finding a way to fight against multi-resistant bacteria by targeting c-di-AMP. We made three different approaches, each approach was accomplished by a subteam, for detailed information, please click the icon on the right panel.</p> | <p>Our project is aimed at finding a way to fight against multi-resistant bacteria by targeting c-di-AMP. We made three different approaches, each approach was accomplished by a subteam, for detailed information, please click the icon on the right panel.</p> | ||
<p style="margin-left: 150px;text-indent: -125px;"><strong>Reporter Team: </strong>development of a reporter system to monitor c-di-AMP levels <i>in vivo</i></p> | <p style="margin-left: 150px;text-indent: -125px;"><strong>Reporter Team: </strong>development of a reporter system to monitor c-di-AMP levels <i>in vivo</i></p> | ||
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"><strong>DAC Team: </strong>characterisation of a diadenylate cyclase that produces c-di-AMP.</p> | "><strong>DAC Team: </strong>characterisation of a diadenylate cyclase that produces c-di-AMP.</p> | ||
<p>After over 3 month of work, we have finally wrapped up. To know more details about our lab work, please visit [[Team:Goettingen/NoteBook|Our Lab Book]].</p> | <p>After over 3 month of work, we have finally wrapped up. To know more details about our lab work, please visit [[Team:Goettingen/NoteBook|Our Lab Book]].</p> | ||
- | <p>We conducted all | + | <p>We conducted all experiments in a S1 level lab in the Department of General Microbiology that is located on the North Campus of the Göttingen University. We strickly stuck to the rules that have to be followed during work in a S1 lab. To know more about safety issues, please [[Team:Goettingen/Safety|visit our safety page]]. |
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</a> | </a> | ||
- | <a href="/Team:Goettingen/Reporter" style="margin-left:50px;display:inline-block;text-decoration:none;"> | + | <a href="/Team:Goettingen/Team/Reporter" style="margin-left:50px;display:inline-block;text-decoration:none;"> |
<h2 style="text-align:center">Reporter Team</h2> | <h2 style="text-align:center">Reporter Team</h2> | ||
<img src="https://static.igem.org/mediawiki/2013/7/75/Goe-reporter.png"/> | <img src="https://static.igem.org/mediawiki/2013/7/75/Goe-reporter.png"/> |
Latest revision as of 13:24, 4 October 2013