Beta-Amyloid Degradation Model

Introduction

This is another degradation model we designed to help UCL 2013 iGEM team with their Beta-Amyloid degradation assays. <a href="https://2013.igem.org/Team:UCL/Project/Degradation" target="_blank">Beta-Amyloid Degradation Assays </a> Beta-Amyloid is known as the component of Amyloids Plaque in association with Alzheimer's disease, in which the target of UCL iGEM this year <a href="https://2013.igem.org/Team:UCL/Background/Alzheimers" target="_blank">Alzheimer's disease (AD)</a>. Matrix metallopeptidase 9 (MMP-9) was discovered to be able to degrade Beta-Amyloid that can be potentially used to cure Alzheimer's disease. The model provides information about how efficient is MMP-9 enzyme to degrade Beta-Amyloids base on the assays from UCL team.

Description

Objective

The Mathematical model is based on MATLAB extension Simbiology, it will predict how long will take to degrade a certain concentration of Beta-Amyloid by a given amount of MMP-9 enzyme. The simulation results can help UCL iGEM team to modify their assays in order to achieve better experimental results. The model can also be used to provide a preliminary prediction of degrading Amyloid Plaque in vivo.

Degradation Assays of UCL 2013 iGEM team