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The beast and its Achilles heel:
A novel target to fight multi-resistant pathogenic bacteria
Another approach of our project is the determination of the 3D structure of diadenylate cyclase (DAC) via crystallography and electron microscopy.
The advantage of the 3D structure of a protein received by crystallography is the identification of possible chemical binding sites due to computational modeling. These chemical compounds may interfere with the activity of the cyclase and could therefore be used as a potential starting point for further drug development.
Due to the fact that the diadenylate cyclase from Bacillus subtilis is difficult to crystallize, the full length protein from Listeria is going to be isolated and crystallized. Furthermore, Streptococcus and Staphylococcus will be used to obtain only the DAC domain of the protein for our analysis.
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