From 2013.igem.org
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| - | <div id="slide"><h1>Presentations</h1> | + | <div id="slide"><h1>Abstract</h1> |
| - | <h3>Overview</h3>
| + | <p id="yo">While low-fat diet and regular exercise are popular approaches to fight with obesity, one easy alternative is simply to increase energy metabolism. In a synthetic biology approach, we are working to create an artificial futile cycle in mammalian cell by introducing glyoxylate enzymes native to bacteria. Past research has shown that mice expressing enzymes constituting an active glyoxylate shunt are shown to be resistant to diet-induced obesity. Our team plans to introduce an inducible system that allows us to couple the sensing of circulating fatty acid concentrations with an inducible circuit of glyoxylate shunt. Our inducible system is intended to prevent the risk of fatty acid deficiency, while facilitating greater fatty acid uptake at higher fatty acid circulating concentrations. Such a system should increase the feasibility of a glyoxylate cycle engineered to function in vivo. </p> |
| - | <p id="yo">Our team thought that presentation is an effective method to fulfill one of our goals that our human practice team set up: provision of information for the public. Our team originally planned to do one presentation for freshmen school of science students in HKUST, but we ended up being involved in five different presentations. Two of the presentations have already been conducted, while the other three presentations will be conducted after the wiki freeze. </p> | + | <br><br> |
| - | <br><h3>Presentations with other iGEM Teams</h3>
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| - | <p id="yo">This year our team had an opportunity to interact with other universities: South University Science and Technology of China (SUSTC), and Chinese University of Hong Kong (CUHK). On August 17th, we met SUSTC at our university. We hosted a semi-formal event where each team had a chance to present and share its project. We also had a Q&A session after each project so that we could discuss the projects in more detail. After the presentations, we ate lunch together and tour around our campus.We also participated in a similar event in CUHK on 24th August. This time, three teams, HKUST, CUHK, and SUSTC iGEM team participated. </p>
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| - | <h3>Presentation for HKUST Students</h3>
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| - | <p id="yo">Our team plan to have two presentations for HKUST students: one for freshmen school of science students and one for school of engineering students. We have already contacted each of the school’s office and confirmed the dates of the presentations. Presentation for school of science students will be conducted on 27th of September and presentation for school of engineering students will take place on 9th of October. During the presentations, we will briefly introduce synthetic biology and the iGEM competition, briefly describe our project, and encourage students to join the next iGEM team. We hope that we will have more variety of student from different majors participating in the iGEM competition next year.</p>
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| - | <h3>Innocarnival</h3>
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| - | <p id="yo">Our team plans to hold a workshop in Innovation Carnival on November 10th. Innovation Carnival (InnoCarnival) is a flagship event of the InnoTech Month organized by the Innovation and Technology Commission (ITC). It aims to provide members of the public to gain hands-on experience of the convenience and fun brought by innovation and technology to daily life. Our talk will be on introducing synthetic biology to the public and share our experience working in the wet lab experiments and human practice activities done to promote synthetic biology to the general and medical community. We believe this will be a great opportunity to educate and promote synthetic biology to Hong Kong community.</p><br>
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Revision as of 10:48, 26 September 2013
Abstract
While low-fat diet and regular exercise are popular approaches to fight with obesity, one easy alternative is simply to increase energy metabolism. In a synthetic biology approach, we are working to create an artificial futile cycle in mammalian cell by introducing glyoxylate enzymes native to bacteria. Past research has shown that mice expressing enzymes constituting an active glyoxylate shunt are shown to be resistant to diet-induced obesity. Our team plans to introduce an inducible system that allows us to couple the sensing of circulating fatty acid concentrations with an inducible circuit of glyoxylate shunt. Our inducible system is intended to prevent the risk of fatty acid deficiency, while facilitating greater fatty acid uptake at higher fatty acid circulating concentrations. Such a system should increase the feasibility of a glyoxylate cycle engineered to function in vivo.
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