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Team:Goettingen/Team/DAC
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===DAC Team=== | ===DAC Team=== | ||
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| - | <p>Another approach of our project is the determination of the 3D structure of diadenylate cyclase (DAC) from the human pathogen <i>Listeria | + | <p>Another approach of our project is the determination of the 3D structure of diadenylate cyclase (DAC) from the human pathogen <i>Listeria monocytogenes</i> by crystallography.</p> |
<p>Once having a 3D structure of a protein in hand potential inhibitor binding sites can be identified by computational modeling. Promising inhibitors that interfere with DAC activity could be used as a starting point for the development of drugs with improved inhibitory efficiency.</p> | <p>Once having a 3D structure of a protein in hand potential inhibitor binding sites can be identified by computational modeling. Promising inhibitors that interfere with DAC activity could be used as a starting point for the development of drugs with improved inhibitory efficiency.</p> | ||
<p>Due to the fact that the DAC from <i>Bacillus subtilis</i> is difficult to purify and thus to crystallize, we have decided to crystallize the DAC protein from <i>Listeria</i> . In addition to this, we will try to crystallize the DACs from <i>Streptococcus</i> and <i>Staphylococcus</i> .</p> | <p>Due to the fact that the DAC from <i>Bacillus subtilis</i> is difficult to purify and thus to crystallize, we have decided to crystallize the DAC protein from <i>Listeria</i> . In addition to this, we will try to crystallize the DACs from <i>Streptococcus</i> and <i>Staphylococcus</i> .</p> | ||
Revision as of 08:57, 27 September 2013
