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The beast and its Achilles heel:
A novel target to fight multi-resistant pathogenic bacteria
Outlook
We made it. The systems worked! Applause for everyone's hard work! However, there are still some bugs needed to be fixed before the reporter systems become really "perfect".
Right now, both our systems are working "too" well. They cannot give a quantitative output of how effective a substance is. They are only able to say just YES or NO, ON or OFF. But we still believe that this is already a great success and good news to us.
What can we do with them now? When Prof. Dr. Stephen Benkovic visited Göttingen this summer, he promised to screen his substance library with our systems. And that is exactly what our systems are for: to screen huge numbers of substances on their ability to turn the lights off. Prof. Dr. Stephen Benkovic's promise is only our first step, with further improvement, our systems will be finally applied in pharmaceutical industries, play the role they should play. Cooperate with Green Coli and save the world with him!
What else is possible with our results you might ask: With the 3D structure of the DAC domain known, bio-informatics all over the world can start designing novel substances which may interfere with the DAC domain and thereby interfere with the c-di-AMP homeostasis in Gram-positive pathogens.
We have big hopes that our work on this project may contribute to stop our world falling back into the dark ages, when the plague eradicated one third of the population of Europe.
At last we would like to invite next year’s iGEM teams, not only the iGEM Team Göttingen 2014, to work on our construct and improve it further.
Keep the green light glowing!
