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The beast and its Achilles heel:
A novel target to fight multi-resistant pathogenic bacteria
Team: Goettingen
Region: Europe
iGEM Year: 2013
Track: Health & Medicine
Project Name: The beast and its Achilles heel: A novel target to fight multi-resistant bacteria
Project Abstract:
Since the discovery of penicillin by Alexander Fleming in 1928, antibiotics have marked a major victory of mankind in the battle against infectious diseases. However, after 90 years, the antibiotics are now losing their old time glory: Bacteria acquire resistance against antibiotics and become unbridled. We must control the use of antibiotics, meanwhile, we need new antibiotics, which can sufficiently eliminate the invaders without hurting the "good" bacteria. Therefore, c-di-AMP, an important, recently discovered signaling molecule in gram-positive bacteria, has come to our sight. Our project is to build a screening system targeting c-di-AMP, which could be applied in novel-drug screening. With this system, the level of c-di-AMP in the cell can be visualized and measured.
