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The beast and its Achilles heel:
A novel target to fight multi-resistant pathogenic bacteria
Created by Wordle
Target: c-di-AMP
Our project is aimed at the development of a simple screening system, which allows the rapid identification and characterization of substances that disturb c-di-AMP homeostasis in pathogenic bacteria. By developing this system, we believe we can help scientist and pharmaceutical companies worldwide to find new and more effective antibiotics against Gram-positive pathogens, for which c-di-AMP is essential. The screening system will be established in the non- pathogenic bacterium E. coli.
We must control the use of antibiotics, meanwhile, we need new antibiotics, which can suffiently eliminate the invaders without hurting the "good" bacteria. Therefore, c-di-AMP, an important, recently discovered signaling molecule in gram-positive bacteria, has come to our sight.
Our project is to build a screening system targeting c-di-AMP, which could be applied in novel-drug screening. With this system, the level of c-di-AMP in the cell can be visualised and measured. In the moment we are still wokring hard in the lab. To see our progress, please visit Our Lab Book.
We seperated our team into three subteams, the Array team, DAC team and the Reporter team. To know about the subteams, please click the icon on the right side.
Our team conducted our work on the North Campus of University Goettingen, in the Microbiology department. All work was done in our S1 level lab. We follow strickly the safety S1 instructions. To know more concerning safety issues, please visit our safety page.
