Team:Edinburgh/Modeling/Modelling Results

== Effect of nutrient environment on growth rate

The model as it is assumes only one generic type of resource which is supposed to combine all resources that the cell needs. As such, we did not have a way to translate between different influx levels of this generic resource and the actual resource environments. We tried to perform growth rate experiments to study how LB medium + different glucose concentrations affect growth rate and we expected to be able to create a conversion table from that. However, the results showed too high variability to be usable - probably because the LB medium is very rich anyway and adding a bit of glucose to it doesn't change a lot.

We used the whole cell model to make several types of predictions:

Effect of gene modifications on growth rate

The graphs below show the values of the growth rate over the time of the simulation from the initial state until steady state is reached. The number shown is the final value of the growth rate at steady state. On the left we can see the results for the unmodified cells, and on the right are the results for the cells modified to produce bioethanol. The results are shown for three different nutrient environments (RE1, RE2, RE3).

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Effect of different nutrient environments on productivity