"
Team:SydneyUni Australia/Modelling Intro
From 2013.igem.org
Revision as of 05:42, 27 September 2013 by Jbergfield (Talk | contribs)
Introduction
A pharmacokinetic model was constructed in order to determine the intracellular concentration of the metabolites as a function of time and determine the rate at which DCA is removed from solution. The synthetic metabolic pathway involves four introduced enzymes which converts the substrate 1,2-dichloroethane (DCA) into the end product glycolate through 3 metabolic intermediates. The concentration of each metabolic species over time was modelled through a system of ordinary differential equations (ODE) where Michaelis-Menton (MM) equations were used to model the kinetics of each enzyme of our constructed metabolic pathway.
With thanks to:
