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The beast and its Achilles heel:
A novel target to fight multi-resistant pathogenic bacteria
DAC Team
Another approach of our project is the determination of the 3D structure of diadenylate cyclase (DAC) from the human pathogen Listeria moncytogenes by crystallography.
Once having a 3D structure of a protein in hand potential inhibitor binding sites can be identified by computational modeling. These chemical compounds may interfere with the activity of the cyclase and could therefore be used as a potential starting point for further drug development.
Due to the fact that the diadenylate cyclase from Bacillus subtilis is difficult to crystallize, the full length protein from Listeria is going to be isolated and crystallized. Furthermore, Streptococcus and Staphylococcus will be used to obtain only the DAC domain of the protein for our analysis.
