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Ethics in synthetic biology

It is not surprising that synthetic biology, the science which adapts and designs living organisms with myriad and undefined applications, has a broad ethical dimension. An ethical dimension … ethical questions … ethics … what on earth? Weren’t we talking exact science here?

Ethics refers to well-founded standards of right and wrong that prescribe what humans ought to do. Ethics is about trying to give answers to questions about the proper way to act or react in certain situations. Note that the ethical course of action is not dependent on social conventions, religious beliefs or the law! As synthetic biology is a new, rapidly expanding scientific field with many anticipated applications and a high impact on society, it is important to address the associated social and ethical issues right from the start of its development. Researchers in synthetic biology have been really keen on doing so as to avoid problems with public perception experienced in other fields. As an iGEM team with a heart for synthetic biology, we want to carry on this tradition and devote some time and space on this wiki to social and ethical implications of this field of research.

The first question that springs to mind when considering new technologies is about the still unknown, potentially harmful consequences. A synthetic organism may have negative effects on the environment or human beings. Such concerns fall under biosafety. Is it acceptable to create something which we don’t know the long-term consequences of? Apart from biosafety, synthetic biology raises also biosecurity concerns, as products of synthetic biology could potentially be used for acts of bioterrorism.

One of the goals of synthetic biology is the creation of new organisms with functions that are not found in nature. Also the creation of minimal organisms from the ground up is an application of synthetic biology. Is the creation of novel entities like microorganisms creating life or merely building a biological machine? Is creating life acceptable? Could this change our view on the concept of life or alter our relationship with other living creatures?

One of the keystones of synthetic biology is the access to an ever growing, open library of standard parts which can be used to create new systems. This doesn’t seem reconcilable with intellectual property rights. Some even propose to ban patents completely in synthetic biology.

It is clear that synthetic biology has an impact on society as a whole. Clear communication with the public is important to save synthetic biology from the same fate as GMOs (genetically modified organisms). But how should we proceed in this communication? How to steer public perception away from the irrational disgust that surrounds genetic manipulation and GMOs? Can the solution be found in more education, more marketing or something else altogether?

We talked about these burning questions with several ethicists and scientists. Each of them was able to shed some new light on certain aspects. By clicking on their photo you can discover what they had to say about the concerns mentioned above. With their varying opinions in the back of our mind, we formulated a viewpoint of our own on these social and ethical issues and introduce a new tool for communicating synthetic biology to the broad public.

• Prof. dr. ir. Wim Soetaert
• Prof. dr. Tom Desmet
• Prof. dr. Filip Buekens
• Prof. dr. Geert De Jaeger

What we take home

It is clear that synthetic biology will lead to tons of new applications in the near future and that it is impossible to foresee all the long-term consequences. Does this mean we should act out of a precautionary principle and not proceed at all? No! We opt, just like the professionals we interviewed, for a more proactionary approach and hope Europe will soon follow this philosophy. We don’t think progress should be halted by worrying about unforeseeable consequences. The focus shouldn’t be on eliminating all risks, as zero-risk is utopian (cfr. Prof. Wim Soetaert). Note that we absolutely agree that foreseeable consequences should be thoroughly evaluated and that a cost-benefit analysis should be made (cfr. Prof. Filip Buekens).