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The beast and its Achilles heel:
A novel target to fight multi-resistant pathogenic bacteria
Team: Goettingen
Region: Europe
iGEM Year: 2013
Track: Health & Medicine
Project Name: The beast and its Achilles heel: A novel target to fight multi-resistant bacteria
Project Abstract:
Since the discovery of penicillin by Alexander Fleming in 1928, antibiotics have marked a major victory of mankind in the battle against infectious diseases. However, after 90 years, the antibiotics are now losing their old time glory: Bacteria acquire resistance against antibiotics and become unbridled. We must control the use of antibiotics, meanwhile, we need new antibiotics, which can sufficiently eliminate the invaders without hurting the "good" bacteria. Therefore, c-di-AMP, an important, recently discovered signaling molecule in gram-positive bacteria, has come to our sight. Our project is to build a screening system targeting c-di-AMP, which could be applied in novel-drug screening. With this system, the level of c-di-AMP in the cell can be visualized and measured.
Achievements
We have:
Register the team, have a great summer, and plan to have fun at the Regional Jamboree.
Successfully complete and submit this iGEM 2013 Judging form.
Create and share a Description of the team's project using the iGEM wiki and the team's parts using the Registry of Standard Biological Parts.
Plan to present a Poster and Talk at the iGEM Jamboree.
Document at least one new standard BioBrick Part or Device used in your project/central to your project and submit this part to the iGEM Registry (submissions must adhere to the iGEM Registry guidelines). A new application of, and outstanding documentation (quantitative data showing the Part's/ Device's function), of a previously existing BioBrick part in the 'Experience' page of that part's Registry entry also counts. Please note you must submit this new part to the iGEM Registry.
For all our parts, we have accomlished:
Description of function
Quantitative data showing the Part or Device function
Acknowedgment of sources and references
We have also:
experimentally validate that at least one new BioBrick Part or Device of your own design and construction works as expected.
document the characterization of this part in the 'Main Page' of that Part's/Device's Registry entry. Submit new parts to the iGEM Parts Registry.
For our parts, we have also fulfilled
Description of function
Quantitative data showing the Part or Device function
Acknowedgment of sources and references
considered the safety issues and filled in the safe forms.
We have also:
improve the function of an existing BioBrick Part or Device (created by another team or your own institution in a previous year), enter this information in the 'Experience' section of that Parts's Registry entry), create a new registry page for the improved part, and submit this part to the iGEM Registry. See Parts
For all improved parts, we fulfilled:
Description of function
Quantitative data showing the Part or Device function
Acknowedgment of sources and references
Help any registered iGEM team from another school or institution by, for example, characterizing a part, debugging a construct, or modeling or simulating their system.
