Team:Paris Bettencourt/Project/Overview

Using Escherichia coli as a model organism we are developing approaches that could lead to eradication of tuberculosis. A drug screen aimed for a specific mycobacterial metabolic pathway, a biosensor for detection of sequence specific antibiotic resistance, a synthetic E. coli which could invade macrophages and kill mycobacteria, and finally a phage carrying sRNA which silence the production of antibiotic resistance proteins thus making antibiotic treatment more effective.