Team:IIT Madras

From 2013.igem.org

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<HEAD>
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{{:Team:IIT Madras/Templates/Header}}<html>
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<TITLE>Basic HTML Sample Page</TITLE>
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<div class="container marketing">
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</HEAD>
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      <div id="myCarousel" class="carousel slide">
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<BODY BGCOLOR="WHITE">
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<CENTER>
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      <ol class="carousel-indicators">
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<H1>Indian Institute of Technology Madras</H1>
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        <li data-target="#myCarousel" data-slide-to="0" class="active"></li>
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<H3>iGEM 2013</H3>
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        <li data-target="#myCarousel" data-slide-to="1" class=""></li>
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<https://upload.wikimedia.org/wikipedia/en/thumb/6/69/IIT_Madras_Logo.svg/200px-IIT_Madras_Logo.svg.png>
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        <li data-target="#myCarousel" data-slide-to="2" class=""></li>
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        <li data-target="#myCarousel" data-slide-to="3" class=""></li>
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      </ol>
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      <div class="carousel-inner">
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        <div class="item active">
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          <img src="https://static.igem.org/mediawiki/2013/d/db/Iitm13_Slide_1.jpg" alt="Second slide" style="height: 500px; width: 100%; display: block;">
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          <div class="container">
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            <div class="carousel-caption">
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              <!--<h1>The Team</h1>
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              <p>Cras justo odio, dapibus ac facilisis in, egestas eget quam. Donec id elit non mi porta gravida at eget metus. Nullam id dolor id nibh ultricies vehicula ut id elit.</p>
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              <p><a class="btn btn-large btn-primary" href="#">More info</a></p>-->
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<marquee behavior="scroll" direction="left" style="
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    color: black;
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    font-weight: bold;
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    font-size: 52px;
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    height: 50px
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;
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    padding-top: 10px;
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">COMBATING SHIGA TOXIN</marquee>
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            </div>
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          </div>
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        </div>
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        <div class="item">
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          <img src="https://static.igem.org/mediawiki/2013/f/f5/Iitm13_Slide_2.jpg" alt="Third slide" style="height: 500px; width: 100%; display: block;">
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          <div class="container">
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            <div class="carousel-caption">
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            </div>
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<div class="item">
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          <img src="https://static.igem.org/mediawiki/2013/a/a7/Iitm13_Slide_3.jpg" alt="Third slide" style="height: 500px; width: 100%; display: block;">
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          <div class="container">
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            <div class="carousel-caption">
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            </div>
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          </div>
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        </div>
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<div class="item">
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          <img src="https://static.igem.org/mediawiki/2013/4/4f/Iitm13_Slide_4.jpg" alt="Third slide" style="height: 500px; width: 100%; display: block;">
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          <div class="container">
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            <div class="carousel-caption">
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            </div>
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        </div>
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<div class="item">
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          <img src="https://static.igem.org/mediawiki/2013/b/b8/Last_slide_edit.jpg" alt="Third slide" style="height: 500px; width: 100%; display: block;">
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          <div class="container">
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            <div class="carousel-caption">
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            </div>
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          </div>
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        </div>
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      </div>
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      <a class="left carousel-control" href="#myCarousel" data-slide="prev"><span class="glyphicon glyphicon-chevron-left"></span></a>
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      <a class="right carousel-control" href="#myCarousel" data-slide="next"><span class="glyphicon glyphicon-chevron-right"></span></a>
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    </div>
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      <hr class="featurette-divider">
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      <div class="row featurette">
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        <div class="col-md-7">
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          Shiga toxin, a worldwide menace, has killed over 1 million people to date and continues to afflict almost 150 million people each year. Currently, there is no treatment for Shiga toxicosis and it leads to complications in the human system like hemolytic uremic syndrome (HUS) and renal failure. Here, we propose a two-fold, novel synthetic biology approach to combat the lethal effect of the toxin. We aim to neutralize the already produced toxin through a nine amino acid Gb3 mimic peptide. We have engineered the Gb3 mimic along with a cellular export signal (ompF) downstream of AHL(quorum sensing molecule) inducible promoter (pLuxR). We also plan to prevent further toxin production by inhibiting the biofilm formation of shigatoxigenic E.coli using indole-3-acetaldehyde (I3A). We expect to validate our approach through functional assays and in silico modelling. Our findings can potentially initiate a new perspective of tackling Shiga toxicosis using synthetic biology tools.
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      </div>
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<div class="col-md-3">
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<img src="https://static.igem.org/mediawiki/2013/6/61/Iitm13_team_pic.JPG" width="100%" style="
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    padding-top: 33px;
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    width: 458px;
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    height: 100%;
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">
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</div>
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</div>

Latest revision as of 02:47, 28 September 2013

Indian Institute of Technology Madras
Shiga toxin, a worldwide menace, has killed over 1 million people to date and continues to afflict almost 150 million people each year. Currently, there is no treatment for Shiga toxicosis and it leads to complications in the human system like hemolytic uremic syndrome (HUS) and renal failure. Here, we propose a two-fold, novel synthetic biology approach to combat the lethal effect of the toxin. We aim to neutralize the already produced toxin through a nine amino acid Gb3 mimic peptide. We have engineered the Gb3 mimic along with a cellular export signal (ompF) downstream of AHL(quorum sensing molecule) inducible promoter (pLuxR). We also plan to prevent further toxin production by inhibiting the biofilm formation of shigatoxigenic E.coli using indole-3-acetaldehyde (I3A). We expect to validate our approach through functional assays and in silico modelling. Our findings can potentially initiate a new perspective of tackling Shiga toxicosis using synthetic biology tools.

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