Team:ITB Indonesia/Project/Overview

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<h2 class="title">Project Overview</h2>
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<p>Aflatoxins are naturally occuring mycotoxins that are mutagenic and carcinogenic. Aflatoxin contamination of foods that are found in many developing countries may cause a serious problem for human health. We are focuses on designing a whole cell biosensor for aflatoxin B1 detection in foods. The biosensor uses Escherichia coli as the chassis to build a genetic circuit using SOS response system to detect DNA damage caused by aflatoxin B1-oxide attack. The SOS response promoter is followed by a reporter gene coding a chromoprotein, therefore the concentration of aflatoxin B1 in food samples could be easily detected by the color change of the bacteria. For the ease of usage, we will design a syringe shaped device with our whole cell biosensor in it. This device would allow aflatoxin B1 to enter the device, but would not permit the cells to leave the device.</p>
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<p>Aflatoxins are naturally occuring mycotoxins that are mutagenic and carcinogenic. Aflatoxin contamination of foods that are found in many developing countries may cause a serious problem for human health. ITB_Indonesia team for iGEM 2013 focuses on designing a whole cell biosensor for aflatoxin B1 detection in foods.</p>
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<p>The biosensor uses Escherichia coli as the chassis to build a genetic circuit using SOS response system to detect DNA damage caused by aflatoxin B1-oxide attack. The SOS response promoter is followed by a reporter gene coding a chromoprotein, therefore the concentration of aflatoxin B1 in food samples could be easily detected by the color change of the bacteria.</p>
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<p>For the ease of usage, we will design a syringe shaped device with our whole cell biosensor in it. This device would allow aflatoxin B1 to enter the device, but would not permit the cells to leave the device.</p>
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<li><a href="https://2013.igem.org/Team:ITB_Indonesia/Project/Aflatoxin">Aflatoxin</a></li>
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<li><a href="https://2013.igem.org/Team:ITB_Indonesia/Project/HowSystemWorks">How System Works</a></li>
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Latest revision as of 21:01, 27 September 2013

Project Overview

Aflatoxins are naturally occuring mycotoxins that are mutagenic and carcinogenic. Aflatoxin contamination of foods that are found in many developing countries may cause a serious problem for human health. ITB_Indonesia team for iGEM 2013 focuses on designing a whole cell biosensor for aflatoxin B1 detection in foods.

The biosensor uses Escherichia coli as the chassis to build a genetic circuit using SOS response system to detect DNA damage caused by aflatoxin B1-oxide attack. The SOS response promoter is followed by a reporter gene coding a chromoprotein, therefore the concentration of aflatoxin B1 in food samples could be easily detected by the color change of the bacteria.

For the ease of usage, we will design a syringe shaped device with our whole cell biosensor in it. This device would allow aflatoxin B1 to enter the device, but would not permit the cells to leave the device.