Team:Imperial College/Modelling beta-amyloid

From 2013.igem.org

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<h2>Introduction</h2>
<h2>Introduction</h2>
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<p align="justify"> This is another degradation model we designed to help UCL 2013 iGEM team with their [https://2013.igem.org/Team:UCL/Project/Degradation Beta-Amyloid Degradation Assays]. Beta-Amyloid is known as the component of Amyloids Plaque in association with Alzheimer's disease[https://2013.igem.org/Team:UCL/Background/Alzheimers Alzheimer's disease (AD)], in which the target of UCL iGEM this year. Matrix metallopeptidase 9 (MMP-9) was discovered to be able to degrade Beta-Amyloid that can be potentially used to cure Alzheimer's disease. The model provides information about how efficient is MMP-9 enzyme to degrade Beta-Amyloids base on the assays from UCL team.</p>   
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<p align="justify"> This is another degradation model we designed to help UCL 2013 iGEM team with their [https://2013.igem.org/Team:UCL/Project/Degradation Beta-Amyloid Degradation Assays]. Beta-Amyloid is known as the component of Amyloids Plaque in association with [https://2013.igem.org/Team:UCL/Background/Alzheimers Alzheimer's disease (AD)], in which the target of UCL iGEM this year. Matrix metallopeptidase 9 (MMP-9) was discovered to be able to degrade Beta-Amyloid that can be potentially used to cure Alzheimer's disease. The model provides information about how efficient is MMP-9 enzyme to degrade Beta-Amyloids base on the assays from UCL team.</p>   
<h2>Description</h2>
<h2>Description</h2>

Revision as of 20:48, 30 September 2013

Contents

Beta-Amyloid Degradation Model

Introduction

This is another degradation model we designed to help UCL 2013 iGEM team with their Beta-Amyloid Degradation Assays. Beta-Amyloid is known as the component of Amyloids Plaque in association with Alzheimer's disease (AD), in which the target of UCL iGEM this year. Matrix metallopeptidase 9 (MMP-9) was discovered to be able to degrade Beta-Amyloid that can be potentially used to cure Alzheimer's disease. The model provides information about how efficient is MMP-9 enzyme to degrade Beta-Amyloids base on the assays from UCL team.

Description

Objective

The Mathematical model is based on MATLAB extension Simbiology, it will predict how long will take to degrade a certain concentration of Beta-Amyloid by a given amount of MMP-9 enzyme. The simulation results can help UCL iGEM team to modify their assays in order to achieve better experimental results. The model can also be used to provide a preliminary prediction of degrading Amyloid Plaque in vivo.

Degradation Assays of UCL 2013 iGEM team


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