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Team:KAIT Japan/Project
From 2013.igem.org
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='''Project'''= | ='''Project'''= | ||
| - | + | =='''abstract'''== | |
| + | <big>Hay fever curE.coli</big> | ||
| + | |||
| + | Japanese on of six people is troubled now by hay fever. These people take a medicine for the hay fever. But, If they take it , they become sleepy. If become sleepy, they cannot work and study. So, we are working on a project to relive hay fever by Escherichia coli to improve these. Mechanism of hay fever When an allergen invades it in the living body, naïve T cell differentiates in Th2. There is more Th2 than Th1, and the mast cell and others that is humoral immunity become active, and inflammation is in this way caused. We perform following four this time. | ||
| + | <p style="text-align:left"> | ||
| + | ①Expression of IL-10 receptor to E.coli. | ||
| + | </p> | ||
| + | <p style="text-align:left"> | ||
| + | ②Phosphorylation of STAT3. | ||
| + | </p> | ||
| + | <p style="text-align:left"> | ||
| + | ③Preparation of gene array with HlyA and L-12 promoter and receiving the STAT3. | ||
| + | </p> | ||
| + | <p style="text-align:left"> | ||
| + | ④Preparation of gene array with TolC and HlyB and HlyD promoter and to receive the STAT3. | ||
| + | </p> | ||
| + | ------ | ||
Revision as of 03:11, 17 August 2013
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ProjectabstractHay fever curE.coli Japanese on of six people is troubled now by hay fever. These people take a medicine for the hay fever. But, If they take it , they become sleepy. If become sleepy, they cannot work and study. So, we are working on a project to relive hay fever by Escherichia coli to improve these. Mechanism of hay fever When an allergen invades it in the living body, naïve T cell differentiates in Th2. There is more Th2 than Th1, and the mast cell and others that is humoral immunity become active, and inflammation is in this way caused. We perform following four this time. ①Expression of IL-10 receptor to E.coli. ②Phosphorylation of STAT3. ③Preparation of gene array with HlyA and L-12 promoter and receiving the STAT3. ④Preparation of gene array with TolC and HlyB and HlyD promoter and to receive the STAT3.
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