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Team:SJTU-BioX-Shanghai
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Overview
| Various methods have been developed to regulate gene expressions on different levels so far. Though widely used in recent study, these methods are difficult to be applied on multiple genes simultaneously and independently due to the complex procedures or the high cost. Therefore, we aim to build a versatile system to control and regulate different genes in an easy and accurate way. | |
| Therefore, we choose several light-controlled gene expression systems and a newly devised tool named CRISPRi to find the solution towards this problem. By changing light intensity, we hope to regulate different genes to different certain expressing levels, thus maximizing producing efficiency. Light sensors are widely used in engineered biosynthetic parts for their sensibility and adjustable intensity, and CRISPRi can knock down different genes easily and specificly by changing the short sequence of its sgRNA part. With advantages of these two systems combined together, parameter determination of multiple gene-expressions will be more predictable and precise in our project, and this novel device will provide us with a promising way of genome-scale metabolism regulation. | File:SJTU-BioX-Shanghai team.png Your team picture |
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