Team:Freiburg/main2

Our Team developed a universal toolkit, termed uniCAS, that enables customizable gene regulation in
mammalian cells. Therefore, we engineered the recently discovered and highly promising CRISPR/Cas9 system.
The regulation is based on the RNA-guided Cas9 protein, which allows targeting of specific DNA sequences.
Our toolkit comprises not only a standardized Cas9 protein,
but also different effector domains for efficient gene activation or repression.