Team:Paris Bettencourt
From 2013.igem.org
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Revision as of 18:10, 22 September 2013
FIGHT TUBERCULOSIS WITH MODERN WEAPONS
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis affecting millions of people over the world. Using Escherichia coli as a model organism we are developing different approaches that could contribute to the fight against TB.
A biosensor that detects the presence of sequence specific antibiotic resistance genes.
A safe and specific high-throughput drug screening method that targets essential mycobacterial metabolic proteins.
A phage system with low fitness cost producing sRNA, which inhibit the synthesis of antibiotic resistance proteins.
An E. coli which invades macrophages and kills mycobacteria.
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