Team:Paris Bettencourt/Project/Trojan Horse




Objectives = make an antibiotic resistant population sensitive to antibiotics

Design a silencing device

Design a genetic element that spread in a population


A silencing system : sRNA

A vector : Phage

A non counter selected system Phagemid system

Sequential method to kill


Characterization of the phagemid system

Experimental set up Results

Sequential killing

Experimental set up Results

Generalization: results for Kan

Origin of resistance

Conclusion and perspectives

Several sRNA on the same plasmid :

Building a library of sRNA :

Possible Applications :

Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
+33 1 44 41 25 22/25
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