Revision as of 09:03, 25 September 2013

Get to know UFMG

File:UFMG.png

UFMG campus

The origins in Brazil of the university go back as far as the 19th century, when it first appeared in the Republic as a continuation of a process that began during the Empire, with the opening of the first institutions of higher education. In Minas Gerais, the first institution of higher education, the School of Pharmacy in Ouro Preto, was founded in 1839. In 1875, the School of Mining was created and, in 1892, already under the Republican regime, the School of Law was established in the ancient capital of the state. In 1898, when the capital was moved to Belo Horizonte, the School of Law was moved as well. Then, in 1907, the Free School of Dentistry was created and, four years later, the Schools of Medicine and Engineering opened. In 1911, the School of Pharmacy was added to the Free School of Dentistry. A group of patriots, the "Inconfidentes," who rebelled against Portuguese domination, conceived of the idea of a university in the state of Minas Gerais, which was founded as the Universidade de Minas Gerais (UMG) in 1927. The state-subsidized private institution brought together the four institutions of higher learning that existed in Belo Horizonte. UMG remained within the state system until 1949, when it was federalized. In the 1940s, a large area in the Pampulha region became the site for the construction of University City. The first structures erected were the Institute of Mechanics (now the Vocational School) and the Main Building. The effective occupation of the campus by the university community started only in the 1960s, when the construction of the buildings that today house most of the academic units was started. The present name – Universidade Federal de Minas Gerais (UFMG) – was not adopted until 1965.When the university was federalized, the Schools of Architecture, Philosophy, and Economics had already been integrated into UFMG. Afterward, as part of its expansion and diversification, the university incorporated and created new units and schools: the Schools of Nursing (1950) and Veterinary Medicine (1961), the Minas Gerais Conservatory of Music (1962), and the Schools of Library (1962), Fine Arts (1963), and Physical Education (1969). In 1968, the organization of UFMG was reformed, which resulted in the division of the old School of Philosophy into various schools and institutes. Thus, the present School of Philosophy and Human Sciences, the Institutes of Biological Sciences and Exact Sciences, the Institute of Geo-Sciences, and the Schools of Letters and Education appeared. Today, firmly established as a model of excellence for the rest of the country, UFMG continues to expand. Agronomy (in Montes Claros), Drama, Control and Automation, Computational Mathematics, Audiology and Speech Pathology, and Nutrition have been added in the last five years, bringing the total of courses offered at the undergraduate level to 48.

The Team

Undergraduates

Graduates

Instructors

History

Our history

In the beginning, we decided to meet weekly to discuss ideas to be developed in iGEM competition. We scheduled a fixed day and time for such discussion and the presence of all members was considered mandatory, as we had in mind that a good project would require the involvement of everybody. So, based on this perspective and considering that most of our colleagues have a knowhow applied to human health, we thought about tropical diseases, like dengue. We had imagined what we could do to precociously diagnose that disease as a measure to provide a fast and precise health care to patients positively diagnosed. Summarizing, we have firstly considered to develop a fast diagnostic tool for dengue, which everyone could use without restrictions, based on a GMO (Genetically Modified Organism). Despite having made a big effort to implement it, many factors turned it an unviable project. First, we didn’t have means to deal with the vector, Aedes aegypti, and we couldn’t establish a viable way to use a GMO to our primary purposes. To try to solve these problems, we invited a researcher from Funed (Fundação Ezequiel Dias - Brazil), Alzira Batista Cecilio, to talk to us about the disease and the fast diagnostic test that she was developing in her studies. This gave us some possibilities, but all of them were too complex to be applied to iGEM in short time. We kept working on building new ideas to be implemented. So, in order to perform a search, we divided our team in groups, which were encouraged to give new and viable ideas to be developed. One of them had a performable idea: check for biomarkers in order to precociously diagnose heart diseases, a priori based in choline detection. But, as this substance is released to blood flow in response to many disturbs, we thought that more biomarkers would be necessary in order to provide a reliable diagnostic. Occurred to us that it would be interesting to add a biomarker already validated and well described. We thought of using creatine-kinase MB (CK-MB), but it does not have an useable receptor or induciblepromoter available, at least one that we could find, to be expressed on our chassis. Troponin was cogitated to be another of our relevant biomarkers, however, it has also shown to be unviable due to the absence of a receptor we could use and or a channel to transport it into the cell. After a intense search, in the end we have agreed to use three biomarkers: Brain Natriuretic Peptide (BNP), Trimethylamine-N-Oxide (TMAO) and Ischemia Modified Albumin (IMA). BNP is a validated biomarker for Acute Coronary Syndrome (ACS) and it has a receptor that could be used to detect BNP, despite of huge size of its receptor (NPR-A) which have a transmembrane site. TMAO, is not considered a validated biomarker, but it came out in our latest searches it could be used as a heart failure predictor, since this substance attacks the heart muscle tissue and provokes necrosis, the main factor of myocardial infarction. IMA is an indicative of any sort of ischemia and it was validated by FDA as a biomarker for ACS, although it is best used as a negative predictor than a positive one (meaning that its absence indicates that everything is probably fine, but its presence means that there’s something wrong).

Brainstorming

Day by Day

Acknowledgment

Our Sponsors

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 {{Team:UFMG Brazil/barra}} {{carlos_teste}}
 =Get to know UFMG=
+[[File:UFMG.png|200px|thumb|right|UFMG campus]]
+The origins in Brazil of the university go back as far as the 19th century, when it first appeared in the Republic as a continuation of a process that began during the Empire, with the opening of the first institutions of higher education. In Minas Gerais, the first institution of higher education, the School of Pharmacy in Ouro Preto, was founded in 1839. In 1875, the School of Mining was created and, in 1892, already under the Republican regime, the School of Law was established in the ancient capital of the state. In 1898, when the capital was moved to Belo Horizonte, the School of Law was moved as well. Then, in 1907, the Free School of Dentistry was created and, four years later, the Schools of Medicine and Engineering opened. In 1911, the School of Pharmacy was added to the Free School of Dentistry. A group of patriots, the "Inconfidentes," who rebelled against Portuguese domination, conceived of the idea of a university in the state of Minas Gerais, which was founded as the Universidade de Minas Gerais (UMG) in 1927. The state-subsidized private institution brought together the four institutions of higher learning that existed in Belo Horizonte. UMG remained within the state system until 1949, when it was federalized. In the 1940s, a large area in the Pampulha region became the site for the construction of University City. The first structures erected were the Institute of Mechanics (now the Vocational School) and the Main Building. The effective occupation of the campus by the university community started only in the 1960s, when the construction of the buildings that today house most of the academic units was started. The present name – Universidade Federal de Minas Gerais (UFMG) – was not adopted until 1965.When the university was federalized, the Schools of Architecture, Philosophy, and Economics had already been integrated into UFMG. Afterward, as part of its expansion and diversification, the university incorporated and created new units and schools: the Schools of Nursing (1950) and Veterinary Medicine (1961), the Minas Gerais Conservatory of Music (1962), and the Schools of Library (1962), Fine Arts (1963), and Physical Education (1969). In 1968, the organization of UFMG was reformed, which resulted in the division of the old School of Philosophy into various schools and institutes. Thus, the present School of Philosophy and Human Sciences, the Institutes of Biological Sciences and Exact Sciences, the Institute of Geo-Sciences, and the Schools of Letters and Education appeared. Today, firmly established as a model of excellence for the rest of the country, UFMG continues to expand. Agronomy (in Montes Claros), Drama, Control and Automation, Computational Mathematics, Audiology and Speech Pathology, and Nutrition have been added in the last five years, bringing the total of courses offered at the undergraduate level to 48.
 =The Team=
 ==Undergraduates==

Team:UFMG Brazil/team

From 2013.igem.org