Team:Paris Bettencourt
From 2013.igem.org
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, that affects millions of people over the world. Using Escherichia coli as a model organism we are developing different approaches that could contribute to the eradication of tuberculosis.
A phage system that detects the presence of sequence specific antibiotic resistance genes.
A safe and specific drug screening method that targets essential mycobacterial metabolic proteins.
A phage system with low fitness cost, producing sRNA which inhibit the synthesis of antibiotic resistance proteins.
An E. coli which invades macrophages and kills mycobacteria.
DETECT
TARGET
INFILTRATE
SABOTAGE
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