Team:Evry

From 2013.igem.org

(Difference between revisions)
 
(265 intermediate revisions not shown)
Line 1: Line 1:
-
<!-- *** What falls between these lines is the Alert Box!  You can remove it from your pages once you have read and understood the alert *** -->
+
{{:Team:Evry/template_home}}
<html>
<html>
-
<div id="box" style="width: 700px; margin-left: 137px; padding: 5px; border: 3px solid #000; background-color: #fe2b33;">
+
 
-
<div id="template" style="text-align: center; font-weight: bold; font-size: large; color: #f6f6f6; padding: 5px;">
+
<div id="mainTextcontainer">
-
This is a template page. READ THESE INSTRUCTIONS.
+
 
 +
<h1>Welcome to the <b><span style="color:#bb8900">Iron Coli Project</span></b> Home Page</h1>
 +
 
 +
<br />
 +
 
 +
<p align="center"><b>The aim of our team this year is to design and realize a <em>treatment for hemochromatosis and thalassemia</em> using synthetic biology with an <em>integrated human practice</em> and <em>modeling approach</em>. </b></p>
 +
 
 +
<br /><br />
 +
 
 +
<div>
 +
<div style="float:right;width:49%;margin-left:1%;">
 +
<h3 align="center">The Team</h3>
 +
<img src="https://static.igem.org/mediawiki/2013/8/89/IronColiTeamatthejamboree.jpg" alt="team photo" width="100%"/>
</div>
</div>
-
<div id="instructions" style="text-align: center; font-weight: normal; font-size: small; color: #f6f6f6; padding: 5px;">
 
-
You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
 
</div>
</div>
-
<div id="warning" style="text-align: center; font-weight: bold; font-size: small; color: #f6f6f6; padding: 5px;">
+
 
-
You <strong>MUST</strong> have all of the pages listed in the menu below with the names specified. PLEASE keep all of your pages within your teams namespace.   
+
<h3 align="center">Abstract</h3>
 +
 
 +
<p>
 +
Our project focuses on developing a novel treatment for <a href="https://2013.igem.org/Team:Evry/Project_diseases"><em>hematological disorders</em></a>  caused by an <a href="https://2013.igem.org/Team:Evry/Project_metabolism"><em>iron overload</em></a>, such as hemochromatosis and thalassemia. These autosomal recessive disorders have symptoms including cirrhosis, arthritis, and heart failure, which result from overabsorption of iron from the duodenum. Although these are among the most common heritable diseases, treatment options are limited. Even today patients are mostly treated by frequent bloodletting, which <a href="https://2013.igem.org/Team:Evry/HumanPractice/Patients_perceptions"><em>many people cannot support</em></a>. The aim of our project is to combat these diseases at the source by developing a therapy that prevents the intestinal absorption of iron.
 +
</p>
 +
 
 +
<p>
 +
We engineer the <i>Escherichia coli</i> <a href="https://2013.igem.org/Team:Evry/Project_FUR"><em>Ferric Uptake Regulation</em></a> (FUR) system using a <a href="https://2013.igem.org/Team:Evry/Inverter"><em>genetic inverter</em></a> so that they produce siderophores (<a href="https://2013.igem.org/Team:Evry/Chelator"><em>iron chelators</em></a>) in response of high concentrations of iron. These engineered bacteria are delivered to the patient's intestine by encapsulating them in an ingestible polymer (<a href="https://2013.igem.org/Team:Evry/Pill_design"><em>capsule</em></a>)  that specifically degrades in the duodenum. Once released into the intestine, the bacteria respond to ambient iron by secreting elevated levels of siderophores, thereby chelating the iron to prevent its absorption by the patient.
 +
</p>
 +
 
 +
 
 +
<script type="text/javascript" src="https://2012.igem.org/Team:Evry/wz_jsgraphics.js?action=raw"></script>
 +
<script type="text/javascript" src="https://2012.igem.org/Team:Evry/mapper.js?action=raw"></script>
 +
 
 +
<div style="clear:both;"></div>
 +
 
 +
<h3 align="center">Overview of the project and the achievements</h3>
 +
 +
<center>
 +
<div align="center">
 +
<img align="center" id="ModMap" src="https://static.igem.org/mediawiki/2013/4/4d/IGEM_Timeline.png" width="850" class="mapper" usemap="#overview_link" style="z-index:500;"/>
 +
 
 +
<map name="overview_link">
 +
<area shape="rect" coords="60,61,210,82" target="Project FUR" href="https://2013.igem.org/Team:Evry/Project_FUR" />
 +
<area shape="rect" coords="60,82,210,103" target="Results" href="https://2013.igem.org/Team:Evry/Results" />
 +
<area shape="rect" coords="60,103,210,124" target="Results" href="https://2013.igem.org/Team:Evry/Results#AceB_GFP" />
 +
<area shape="rect" coords="228,63,378,82" target="Inverter" href="https://2013.igem.org/Team:Evry/Inverter" />
 +
<area shape="rect" coords="228,101,378,120" target="Model"  nohref="nohref" />
 +
<area shape="rect" coords="228,82,378,101" target="Results" href="https://2013.igem.org/Team:Evry/Results#Inverter" />
 +
<area shape="rect" coords="399,63,556,80" target="Chelator" href="https://2013.igem.org/Team:Evry/Chelator" />
 +
<area shape="rect" coords="399,103,556,120" target="Results" href="https://2013.igem.org/Team:Evry/Chelator#caracterization_siderophore" />
 +
<area shape="rect" coords="399,83,556,100" target="Chelator" href="https://2013.igem.org/Team:Evry/Chelator#Second_design" />
 +
<area shape="rect" coords="633,76,841,94" target="Expert consultation" href="https://2013.igem.org/Team:Evry/HumanPractice/Expert_consultation" />
 +
<area shape="rect" coords="633,156,841,174" target="Philosophy" href="https://2013.igem.org/Team:Evry/Philosophy" />
 +
<area shape="rect" coords="633,136,841,154" target="Safety" href="https://2013.igem.org/Team:Evry/Safety" />
 +
<area shape="rect" coords="633,116,841,134" target="Seminar" href="https://2013.igem.org/Team:Evry/Seminar" />
 +
<area shape="rect" coords="633,96,841,114" target="Patients perceptions" href="https://2013.igem.org/Team:Evry/HumanPractice/Patients_perceptions" />
 +
 
 +
<!--
 +
<area shape="rect" coords="443,457,659,474"  href="https://2013.igem.org/Team:Evry/Model1#Results" />
 +
<area shape="rect" coords="443,517,659,547"  href="https://2013.igem.org/Team:Evry/Model1#Conclusion" />
 +
<area shape="rect" coords="443,497,659,514"  href="https://2013.igem.org/Team:Evry/Model1#Results" />
 +
<area shape="rect" coords="443,477,659,494"  href="https://2013.igem.org/Team:Evry/Model1#Results" />
 +
<area shape="rect" coords="164,398,419,414"  href="https://2013.igem.org/Team:Evry/Model3#Description" />
 +
<area shape="rect" coords="164,458,419,474"  href="https://2013.igem.org/Team:Evry/Model3#Conclusion" />
 +
<area shape="rect" coords="164,438,419,454"  href="https://2013.igem.org/Team:Evry/Metabolism_model" />
 +
<area shape="rect" coords="164,418,419,434"  href="https://2013.igem.org/Team:Evry/Model3#Results" />
 +
-->
 +
 
 +
<area shape="rect" coords="118,276,283,294"  target="Norms from the European Pharmacopeoa" href="https://2013.igem.org/Team:Evry/Pill_design#norm" />
 +
<area shape="rect" coords="118,296,283,314"  target="Overcoming the acidity" href="https://2013.igem.org/Team:Evry/Pill_design#acidity" />
 +
<area shape="rect" coords="303,276,497,294"  target="Dissolution in the jejunum" href="https://2013.igem.org/Team:Evry/Pill_design#jejunum"/>
 +
<area shape="rect" coords="303,294,497,312" target="Survival after the process" href="https://2013.igem.org/Team:Evry/Pill_design#conclusion" />
 +
 
 +
<area shape="rect" coords="631,175,794,195" href="https://2013.igem.org/Team:Evry/Economy" />
 +
<area shape="rect" coords="159,402,448,423" href="https://2013.igem.org/Team:Evry/Modelmeta1" />
 +
<area shape="rect" coords="159,443,448,464" href="https://2013.igem.org/Team:Evry/Metabolism_model" />
 +
<area shape="rect" coords="159,381,448,402" href="https://2013.igem.org/Team:Evry/Modelmeta2" />
 +
<area shape="rect" coords="159,422,448,443" href="https://2013.igem.org/Team:Evry/Modelmeta3" />
 +
<area shape="rect" coords="159,463,448,484" href="https://2013.igem.org/Team:Evry/pop_scale" />
 +
<area shape="rect" coords="159,483,448,504" href="https://2013.igem.org/Team:Evry/Modelmeta3" />
 +
 
 +
<area shape="rect" coords="462,464,595,484" href="https://2013.igem.org/Team:Evry/Modeltr1" />
 +
<area shape="rect" coords="462,484,595,504" href="https://2013.igem.org/Team:Evry/Modeltr1" />
 +
<area shape="rect" coords="462,504,595,524" href="https://2013.igem.org/Team:Evry/Modeltr2" />
 +
<area shape="rect" coords="464,524,673,558" href="https://2013.igem.org/Team:Evry/Modeltr2" />
 +
 
 +
</map>
</div>
</div>
-
</div>
+
</center>
-
</html>
+
-
<!-- *** End of the alert box *** -->
 
 +
<div style="clear:both;">
 +
</div>
-
{|align="justify"
+
</div>
-
|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
+
</div>
-
|[[Image:Evry_logo.png|200px|right|frame]]
+
-
|-
+
-
|
+
-
''Tell us more about your project.  Give us background.  Use this as the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
+
-
|}
+
<!--
 +
<script type="text/javascript">
 +
alert("Our team is proud to announce that we were awarded a gold medal and the Best Human Practice price at the european jamboree! We are going to Boston.\n\nUnfortunately, we are missing a few thousands of euros to be capable of finishing the competition. If you are a company and would like to sponsor our team, please contact us at igemevry@gmail.com.")
 +
</script>
 +
-->
-
<!--- The Mission, Experiments --->
+
</html>
-
{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
+
{{:Team:Evry/foot}}
-
!align="center"|[[Team:Evry|Home]]
+
-
!align="center"|[[Team:Evry/Team|Team]]
+
-
!align="center"|[https://igem.org/Team.cgi?year=2013&team_name=Evry Official Team Profile]
+
-
!align="center"|[[Team:Evry/Project|Project]]
+
-
!align="center"|[[Team:Evry/Parts|Parts Submitted to the Registry]]
+
-
!align="center"|[[Team:Evry/Modeling|Modeling]]
+
-
!align="center"|[[Team:Evry/Notebook|Notebook]]
+
-
!align="center"|[[Team:Evry/Safety|Safety]]
+
-
!align="center"|[[Team:Evry/Attributions|Attributions]]
+
-
|}
+

Latest revision as of 18:38, 28 October 2013

Iron coli project

Welcome to the Iron Coli Project Home Page


The aim of our team this year is to design and realize a treatment for hemochromatosis and thalassemia using synthetic biology with an integrated human practice and modeling approach.



The Team

team photo

Abstract

Our project focuses on developing a novel treatment for hematological disorders caused by an iron overload, such as hemochromatosis and thalassemia. These autosomal recessive disorders have symptoms including cirrhosis, arthritis, and heart failure, which result from overabsorption of iron from the duodenum. Although these are among the most common heritable diseases, treatment options are limited. Even today patients are mostly treated by frequent bloodletting, which many people cannot support. The aim of our project is to combat these diseases at the source by developing a therapy that prevents the intestinal absorption of iron.

We engineer the Escherichia coli Ferric Uptake Regulation (FUR) system using a genetic inverter so that they produce siderophores (iron chelators) in response of high concentrations of iron. These engineered bacteria are delivered to the patient's intestine by encapsulating them in an ingestible polymer (capsule) that specifically degrades in the duodenum. Once released into the intestine, the bacteria respond to ambient iron by secreting elevated levels of siderophores, thereby chelating the iron to prevent its absorption by the patient.

Overview of the project and the achievements

Retrieved from "http://2013.igem.org/Team:Evry"