Ganciclovir Distribution

Ganciclovir is the prodrug to kill the bacteria. See the principle of killing:(). The bacteria needs to be killed at a mild rate. So it is important to predict the concentration of ganciclovir in the body, especially in the tumor zone. In this part we used Physiologically based pharmacokinetic model(PBPK) to describe the distribution of the drug in different tissues of body.

Physiologically Based Pharmacokinetic Model

The pharmacokinetic model is a useful tool to predict drug concentrations in human tissues. The essence of pharmacokinetic model is

1). Compartmental method. Different tissues in human are modeled as compartments, like lung, kidney and fat. Within the compartment, it is assumed that drug distribution is uniform. The blood flows from one compartment to another and brings the drug throughout the body.

2). Diffusion limitation. Diffusion limitation is illustrated by the speed of blood flow and the affinity of the compartment to the drug. Some organs have a higher rate of blood flow, like lung and heart.

References