Team:USTC CHINA/Modeling/
From 2013.igem.org
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<p>To eliminate potential safety problem, we constructed a suicide system on engineered bacteria to ensure biosafety. As the only one loaded with kill switch, the engineered reporter bacteria is responsible for eliminating all siblings in T-vaccine. | <p>To eliminate potential safety problem, we constructed a suicide system on engineered bacteria to ensure biosafety. As the only one loaded with kill switch, the engineered reporter bacteria is responsible for eliminating all siblings in T-vaccine. | ||
Killing is mediated by the exported toxic protein SdpC. Extracellular SdpC induces the synthesis of an immunity protein, SdpI, which protects toxin-producing cells from being killed. SdpI, a polytopic membrane protein, is encoded by a two-gene operon under sporulation control that contains the gene for an autorepressor, SdpR.</p> | Killing is mediated by the exported toxic protein SdpC. Extracellular SdpC induces the synthesis of an immunity protein, SdpI, which protects toxin-producing cells from being killed. SdpI, a polytopic membrane protein, is encoded by a two-gene operon under sporulation control that contains the gene for an autorepressor, SdpR.</p> | ||
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<a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/KillSwitch">read more about Kill Switch</a> | <a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/KillSwitch">read more about Kill Switch</a> | ||
</div> | </div> |
Revision as of 09:26, 27 September 2013