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Team:UC Davis
From 2013.igem.org
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| - | Welcome to the 2013 UC Davis iGEM Wiki!<br></br>We have a created a novel class of transcription factors known as RiboTALs. We sought to address the constraints placed on circuit design by the limited number of well characterized promoters at our disposal, and their respective transcription factors. Our device generates Transcriptional Activator-Like (TAL) effectors which can be engineered to bind to and repress any sequence of interest. The production of these repressor proteins is controlled by riboswitches, and thus inherit the potential of riboswitches to respond to any inducer molecule due to their engineerable and modular aptamer binding domains. <br></br> We also | + | Welcome to the 2013 UC Davis iGEM Wiki!<br></br>We have a created a novel class of transcription factors known as RiboTALs. We sought to address the constraints placed on circuit design by the limited number of well characterized promoters at our disposal, and their respective transcription factors. Our device generates Transcriptional Activator-Like (TAL) effectors which can be engineered to bind to and repress any sequence of interest. The production of these repressor proteins is controlled by riboswitches, and thus inherit the potential of riboswitches to respond to any inducer molecule due to their engineerable and modular aptamer binding domains. <br></br> We also designed and implemented a Biobrick characterization database called The Depot to promote sharing and openness in iGEM.</p> |
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Revision as of 00:03, 28 September 2013
Our Sponsors
Project BackgroundLearn about how we combine riboswitches and TALs into robust orthogonal mechanisms for inducible repression. |
ResultsCheck out the cool results of our experiments with RiboTALs. |
Human PracticesTake a look at how we promote sharing in iGEM through The Depot, an open BioBrick characterization database. |
Judging CriteriaHere's the criteria that we met for this year's team. |
Welcome
Welcome to the 2013 UC Davis iGEM Wiki!
We have a created a novel class of transcription factors known as RiboTALs. We sought to address the constraints placed on circuit design by the limited number of well characterized promoters at our disposal, and their respective transcription factors. Our device generates Transcriptional Activator-Like (TAL) effectors which can be engineered to bind to and repress any sequence of interest. The production of these repressor proteins is controlled by riboswitches, and thus inherit the potential of riboswitches to respond to any inducer molecule due to their engineerable and modular aptamer binding domains.
We also designed and implemented a Biobrick characterization database called The Depot to promote sharing and openness in iGEM.
