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Team:TU-Eindhoven/ProteinSelection
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==CEST Based Marker Proteins== | ==CEST Based Marker Proteins== | ||
| - | To create bacteria with the ability to generate contrast on a CEST MRI scan, polypeptides that have that ability had to be found. Various solutions based on short Lysine, Arganine, Threonine or Serine rich sequences were proposed.{{:Team:TU-Eindhoven/Template:Ref | author=M.T. McMahon | title=New "Multicolor" Polypeptide Diamagnetic Chemical Exchange Saturation Transfer (DIACEST) Contrast Agents for MRI | journal=Magnetic Resonance in Medicine | edition=60 | pages=803-812 | year=2008 }} | + | {{:Team:TU-Eindhoven/Template:Lead}}To create bacteria with the ability to generate contrast on a CEST MRI scan, polypeptides that have that ability had to be found. Various solutions based on short Lysine, Arganine, Threonine or Serine rich sequences were proposed.{{:Team:TU-Eindhoven/Template:Ref | author=M.T. McMahon | title=New "Multicolor" Polypeptide Diamagnetic Chemical Exchange Saturation Transfer (DIACEST) Contrast Agents for MRI | journal=Magnetic Resonance in Medicine | edition=60 | pages=803-812 | year=2008 }} However, it is hard to predict how well these sequences will express in bacteria and whether they are sufficiently stable in vivo. To avoid these problems a new approach was taken. The suitability as a CEST Based Marker was estimated for proteins of which the structure is already clarified.{{:Team:TU-Eindhoven/Template:LeadEnd}} |
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==References== | ==References== | ||
{{:Team:TU-Eindhoven/Template:RefList}} | {{:Team:TU-Eindhoven/Template:RefList}} | ||
Revision as of 18:02, 25 May 2013
CEST Based Marker Proteins
To create bacteria with the ability to generate contrast on a CEST MRI scan, polypeptides that have that ability had to be found. Various solutions based on short Lysine, Arganine, Threonine or Serine rich sequences were proposed.{{{id}}}M.T. McMahon, New "Multicolor" Polypeptide Diamagnetic Chemical Exchange Saturation Transfer (DIACEST) Contrast Agents for MRI. Magnetic Resonance in Medicine 60, 803-812 (2008) However, it is hard to predict how well these sequences will express in bacteria and whether they are sufficiently stable in vivo. To avoid these problems a new approach was taken. The suitability as a CEST Based Marker was estimated for proteins of which the structure is already clarified.
References
