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| - | <html>
| + | {{Team:UFMG Brazil/barra}} |
| - | <head>
| + | {{carlos_teste}} |
| - | <script type="text/x-mathjax-config">
| + | {{Cardbio_barra_home_modeling}} |
| - | MathJax.Hub.Config({
| + | {{Cardbio_barra_modeling}} |
| - | tex2jax:
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| - | {
| + | |
| - | inlineMath: [['$','$'],['\\(','\\)']]
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| - | }
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| - | }); | + | |
| - | </script>
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| - | <script type='text/javascript' src='http://cdn.mathjax.org/mathjax/latest/MathJax.js?config=TeX-AMS-MML_HTMLorMML'></script>
| + | |
| - | </head>
| + | |
| | | | |
| - | <body>
| + | =Modeling= |
| - | This is the sketch of our modeling.
| + | |
| - | We are going to use TMAO as a biomarker.
| + | |
| | | | |
| - | <div id="variables_description"> | + | <html> |
| - | <p> $M$ is TMAO. </p>
| + | Given the complexity regarding both detection systems, we made computational models to describe them, and to try and predict their behaviour, so as to aid on the lab experiments. Check out our models for <a href='https://2013.igem.org/Team:UFMG_Brazil/TMAO'>TMAO</a> and <a href='https://2013.igem.org/Team:UFMG_Brazil/IMA'>IMA</a>. |
| - | <p> $T$ is TorT. </p>
| + | |
| - | <p> $TM$ is the complex of T and M. </p>
| + | |
| - | <p> $S$ is TorS. </p>
| + | |
| - | <p> $STM$ is the complex of S and TM. </p>
| + | |
| - | <p> $R$ is TorR. </p>
| + | |
| - | <p> $R^{ *}$ is TorR Phosophorilated. </p>
| + | |
| - | </div>
| + | |
| - | <p> Reactions: </p>
| + | |
| - | \[
| + | |
| - | | + | |
| - | \begin{aligned}
| + | |
| - | \\
| + | |
| - | $M+T{{k_{1} \atop\displaystyle\longrightarrow} \atop {\displaystyle\longleftarrow \atop k_{-1}}}TM$
| + | |
| - | \\
| + | |
| - | $2TM+S{{k_{2} \atop\displaystyle\longrightarrow} \atop {\displaystyle\longleftarrow \atop k_{-2}}}STM$
| + | |
| - | \\
| + | |
| - | $STM+R{{k_{3} \atop\displaystyle\longrightarrow} \atop {\displaystyle\longleftarrow \atop k_{-3}}} X {{k_{cat}\atop\longrightarrow} \atop {\quad \atop \quad }}R^{ *} + STM$
| + | |
| - | \\
| + | |
| - | $R^{ *} + P {{\displaystyle\longrightarrow} \atop {\displaystyle\longleftarrow}} PR^{ *}$
| + | |
| - | \\
| + | |
| - | \begin{eqnarray}
| + | |
| - | \begin{cases}
| + | |
| - | {d M(t)\over d t}&=& -k_1 \cdot M\cdot T + k_{-1}\cdot TM\\\\
| + | |
| - | \\\\
| + | |
| - | {d T(t)\over d t}&=& -k_1 \cdot M\cdot T + k_{-1}\cdot TM\\\\
| + | |
| - | \\\\
| + | |
| - | {d TM(t)\over d t}&=& k_1 \cdot M\cdot T - k_{-1}\cdot TM - k_2\cdot TM^{2} \cdot S + k_{-2} \cdot STM\\\\
| + | |
| - | \\\\
| + | |
| - | {d S(t)\over d t}&=& -k_2 \cdot S\cdot TM^{2} - k_{-1}\cdot TM - k_2\cdot TM^{2} \cdot S + k_{-2} \cdot STM\\\\
| + | |
| - | \\\\
| + | |
| - | {d STM(t)\over d t}&=& k_2 \cdot TM^{2} \cdot S - k_{-2}\cdot STM \\\\
| + | |
| - | \\\\
| + | |
| - | {d R^{ *}(t)\over d t}&=& k_{cat}\cdot STM \over{k_m + STM}\\\\
| + | |
| - | \\\\
| + | |
| - | {d mRNA(t)\over d t}&=& {\alpha \cdot R^{ *^{\gamma}} \over{\beta + R^{ *^{\gamma}}}} - \mu \cdot mRNA\\\\
| + | |
| - | \\
| + | |
| - | \end{cases}
| + | |
| - | \end{eqnarray}
| + | |
| - | \\
| + | |
| - | \end{aligned}
| + | |
| - | \]
| + | |
| - | | + | |
| - | </div> | + | |
| | </html> | | </html> |
| | | | |
| - | <!-- *** End of the alert box *** -->
| + | {{Team:UFMG Brazil/sponsor}} |
| - | | + | |
| - | | + | |
| - | {| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center" | + | |
| - | !align="center"|[[Team:UFMG_Brazil|Home]]
| + | |
| - | !align="center"|[[Team:UFMG_Brazil/Team|Team]]
| + | |
| - | !align="center"|[https://igem.org/Team.cgi?year=2013&team_name=UFMG_Brazil Official Team Profile]
| + | |
| - | !align="center"|[[Team:UFMG_Brazil/Project|Project]]
| + | |
| - | !align="center"|[[Team:UFMG_Brazil/Parts|Parts Submitted to the Registry]]
| + | |
| - | !align="center"|[[Team:UFMG_Brazil/Modeling|Modeling]]
| + | |
| - | !align="center"|[[Team:UFMG_Brazil/Notebook|Notebook]]
| + | |
| - | !align="center"|[[Team:UFMG_Brazil/Safety|Safety]]
| + | |
| - | !align="center"|[[Team:UFMG_Brazil/Attributions|Attributions]]
| + | |
| - | |}
| + | |
| - | | + | |
| - | | + | |
| - | If you choose to include a '''Modeling''' page, please write about your modeling adventures here. This is not necessary but it may be a nice list to include.
| + | |
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