Team:Freiburg

From 2013.igem.org

(Difference between revisions)

Latest revision as of 23:52, 9 April 2014

Our Team developed a universal toolkit, termed uniCAS, that enables customizable gene regulation in mammalian cells. Therefore, we engineered the recently understood and highly promising CRISPR/Cas9 system.
The regulation is based on the RNA-guided dCas9 protein, which allows specific targeting of DNA sequences. Our toolkit comprises not only a standardized dCas9 protein, but also different effector domains for efficient gene activation or repression.

Our Project

Activation

Repression

Epigenetics

Multiple targeting

uniBAss

Light induction

Highlights

All about our
project in one
slide show!

Manual

Use our Toolkit
to regulate your
genes!

Human

Practice

News

Have a look at our achievements in Lyon & Boston!

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     <img id="klammer_gross_links" src="https://static.igem.org/mediawiki/2013/e/e0/Freiburg_2013_main2_Rahmen_gross_links.png">
-    <div id="text">
+    <div id="text1">
     <div id="text_gross" align="left"> <a href="https://2013.igem.org/Team:Freiburg/Project/1#abstract"> Abstract </a> </div>
     Our Team developed a universal toolkit,  termed uniCAS, that enables customizable gene
-      regulation in mammalian cells.  Therefore, we engineered the recently discovered and highly promising
+      regulation in mammalian cells.  Therefore, we engineered the recently understood and highly promising
       CRISPR/Cas9 system. <br>
-       The regulation is based on the RNA-guided Cas9 protein, which allows targeting of specific DNA sequences.
+       The regulation is based on the RNA-guided dCas9 protein, which allows specific targeting of DNA sequences.
-       Our toolkit comprises not only a standardized Cas9 protein,  but also different effector domains for
+       Our toolkit comprises not only a standardized dCas9 protein,  but also different effector domains for
        efficient gene activation or repression.
 </div>
@@ Line 256: / Line 257: @@
 </a>
-<li style="margin-left: -40px; padding-bottom:12px;"><a href="https://2013.igem.org/Team:Freiburg/Project/effector#KRAB">
+<li style="margin-left: -40px; padding-bottom:12px;"><a href="https://2013.igem.org/Team:Freiburg/Project/effector#repression">
 <span> Repression </span>
 <img  src="https://static.igem.org/mediawiki/2013/e/e7/Repression_freiburg_13.png" style="height:55px;">
@@ Line 262: / Line 263: @@
 </a>
-<li style="margin-bottom:-30px;"><a href="https://2013.igem.org/Team:Freiburg/Project/effector#G9a">
+<li style="margin-bottom:-30px;"><a href="https://2013.igem.org/Team:Freiburg/Project/effector#epigenetics">
-<span> Stable Repression </span>
+<span> Epigenetics </span>
 <img src="https://static.igem.org/mediawiki/2013/3/31/Freiburg_2013_main2_Epigenetic.png">
 </li>
@@ Line 273: / Line 274: @@
 <ul style="margin-left:160px">
-<li style="margin-top: -30px; padding-bottom:10px;"><a href="https://2013.igem.org/Team:Freiburg/Project/crrna#multiple_targeting">
+<li style="margin-top: -30px; padding-bottom:10px;"><a href="https://2013.igem.org/Team:Freiburg/Project/crrna">
    <img src="https://static.igem.org/mediawiki/2013/b/bb/Freiburg_2013_main2_Multiple_Targeting.png">
 <span> Multiple targeting </span>
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     <div id="text-box3">
        <div id="text_gross" align="left"><a style="position:absolute; top:678px; left:60px; z-index:2" href="https://2013.igem.org/Team:Freiburg/Highlights"> Highlights </div> </a>
-   <p style="position:absolute; top:720px; left:60px" > All about our <br> project on one <br> page! </p>
+   <p style="position:absolute; top:720px; left:60px" > All about our <br> project in one <br> slide show! </p>
   <img src="https://static.igem.org/mediawiki/2013/0/0e/Freiburg_2013_main2_Highlights5.png" height="190" style="position:absolute; top:614px; left:105px; z-index:1">
     </div>
@@ Line 381: / Line 382: @@
     <div id="text-box6">
-      <div id="text_gross" align="left"> <a style="position:absolute; top:678px; left:910px; z-index:2" href="https://2013.igem.org/Team:Freiburg/Team2"> Team  </a></div>
+<div id="text_gross" align="left"> <a style="position:absolute; top:678px; left:910px; z-index:2" href="https://2013.igem.org/Team:Freiburg/News"> News  </a></div>
-   <img src="https://static.igem.org/mediawiki/2013/9/91/Freiburg_2013_main2_teamkachel_TEAM2.png" height="140" style="position:absolute; top:685px; left:900px; z-index:1">
+<p style="padding-top:10px;">
+Have a look at our achievements in Lyon & Boston!
+</p>
+<img src="https://static.igem.org/mediawiki/2013/5/56/Best-foundational-advance-2013-freiburg.png" height="130" style="position:absolute; top:600px; left:980px; z-index:1">
     </div>
+</div>
     <img id="klammer_klein_rechts" src="https://static.igem.org/mediawiki/2013/8/82/Freiburg_2013_main2_Rahmen_gross_rechts.png">
    </td>
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