Team:Freiburg/description

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Project description in multiple languages
 
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<div><b>Gene Regulation – Multiple Targets – Activation – Optogenetics – Repression – Inducibility – Epigenetics </b></div><br>
<div><b>Gene Regulation – Multiple Targets – Activation – Optogenetics – Repression – Inducibility – Epigenetics </b></div><br>
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<p id="h3"> Français </p>
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<div><b> Régulation Génétique – Destinations Multiples – Activation – Optogénétique – Répression – Induction – Épigénétique </b></div><br>
<div><b> Régulation Génétique – Destinations Multiples – Activation – Optogénétique – Répression – Induction – Épigénétique </b></div><br>
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<p id="h3"> Español </p>
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<div><b>Regulación Genética – Múltiples Focos – Activación – Optogenética – Represión – Inducción – Epigenética </b></div><br>
<div><b>Regulación Genética – Múltiples Focos – Activación – Optogenética – Represión – Inducción – Epigenética </b></div><br>
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<p id="h3"> Português </p>
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<div><b> Regulação Genética – Múltiplos Focos – Activação – Optogenética – Repressão – Indução – Epigenética </b></div><br>
<div><b> Regulação Genética – Múltiplos Focos – Activação – Optogenética – Repressão – Indução – Epigenética </b></div><br>
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<p id="h3"> Deutsch </p>
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<p id="h2"> Deutsch </p>
<div><b> Genregulation – Multiple Targets – Aktivierung – Optogenetik – Reprimierung – Induzierbarkeit – Epigenetik </b></div><br>
<div><b> Genregulation – Multiple Targets – Aktivierung – Optogenetik – Reprimierung – Induzierbarkeit – Epigenetik </b></div><br>

Latest revision as of 01:34, 29 October 2013


English

Gene Regulation – Multiple Targets – Activation – Optogenetics – Repression – Inducibility – Epigenetics

Just imagine there was a tool that combined all these aspects of lab work. A tool, that was able to rule several genes at once; a tool that allowed highly specific gene modulation via stimulus induction; a tool that would be a new approach to gene regulation.


This year’s Freiburg iGEM Team uses the prokaryotic CRISPR/Cas system to enable multiple endogenous gene regulation with minimal effort. The regulation is based on a protein-RNA-DNA interaction. Customizable RNAs function as a guide for our protein in order to target specific DNA sequences. By fusing effector domains to this protein, we aim at developing a tool for multiple and inducible gene activation and repression. Despite the system's prokaryotic origin, gene target sequences are adjustable for various organisms, offering a broad application variety of our tool. Due to its great potential, the CRISPR/Cas system has become of increasing importance in current research and can be implemented in a number of novel and interesting applications, such as gene therapy or tissue engineering.