Team:Freiburg
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+ | <div style="min-height:600px; margin-top:230px;" > | ||
+ | |||
+ | <!-- ######################################################################################## | ||
+ | |||
+ | TABLE OBEN | ||
+ | |||
+ | ######################################################################################## --> | ||
+ | |||
+ | |||
+ | |||
+ | <table id="table_viereck"> | ||
+ | |||
+ | <!-- ######################################################################################## | ||
+ | |||
+ | ABSTRACT | ||
+ | ######################################################################################## --> | ||
+ | <tr> | ||
+ | <td width="450px"> | ||
+ | <img id="klammer_gross_links" src="https://static.igem.org/mediawiki/2013/e/e0/Freiburg_2013_main2_Rahmen_gross_links.png"> | ||
+ | <div id="text1"> | ||
+ | <div id="text_gross" align="left"> <a href="https://2013.igem.org/Team:Freiburg/Project/1#abstract"> Abstract </a> </div> | ||
- | + | Our Team developed a universal toolkit, termed uniCAS, that enables customizable gene | |
- | + | regulation in mammalian cells. Therefore, we engineered the recently understood and highly promising | |
- | + | CRISPR/Cas9 system. <br> | |
- | + | The regulation is based on the RNA-guided dCas9 protein, which allows specific targeting of DNA sequences. | |
- | + | Our toolkit comprises not only a standardized dCas9 protein, but also different effector domains for | |
- | + | efficient gene activation or repression. | |
- | + | </div> | |
- | + | ||
- | / | + | <img id="klammer_gross_rechts" src="https://static.igem.org/mediawiki/2013/8/82/Freiburg_2013_main2_Rahmen_gross_rechts.png"> |
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- | / | + | </td> |
- | + | ||
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- | + | ||
- | + | ||
- | + | <!-- ######################################################################################## | |
- | + | ||
- | + | ||
- | + | ||
- | + | PROJECT | |
- | + | ||
- | + | ||
- | + | ||
+ | ######################################################################################## --> | ||
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+ | <td> | ||
- | / | + | <img id="klammer_gross_links" src="https://static.igem.org/mediawiki/2013/e/e0/Freiburg_2013_main2_Rahmen_gross_links.png"> |
+ | |||
+ | <div id="text-box2"> | ||
+ | |||
+ | <div id="text_gross" align="left"><a href="https://2013.igem.org/Team:Freiburg/Project/1"> Our Project </a></div> | ||
+ | |||
+ | <div> | ||
- | + | <ul style="margin-left:40px;"> | |
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- | + | <li style="margin-top:-30px; padding-bottom:12px;"><a href="https://2013.igem.org/Team:Freiburg/Project/effector#activation"> | |
- | + | <span> Activation </span> | |
- | . | + | <img src="https://static.igem.org/mediawiki/2013/0/03/Freiburg_2013_main2_Activation.png" style="height:65px;"> |
- | . | + | </li> |
+ | </a> | ||
+ | <li style="margin-left: -40px; padding-bottom:12px;"><a href="https://2013.igem.org/Team:Freiburg/Project/effector#repression"> | ||
+ | <span> Repression </span> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/e/e7/Repression_freiburg_13.png" style="height:55px;"> | ||
+ | </li> | ||
+ | </a> | ||
+ | |||
+ | <li style="margin-bottom:-30px;"><a href="https://2013.igem.org/Team:Freiburg/Project/effector#epigenetics"> | ||
+ | <span> Epigenetics </span> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/3/31/Freiburg_2013_main2_Epigenetic.png"> | ||
+ | </li> | ||
+ | </a> | ||
+ | </ul> | ||
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- | + | <ul style="margin-left:160px"> | |
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+ | <li style="margin-top: -30px; padding-bottom:10px;"><a href="https://2013.igem.org/Team:Freiburg/Project/crrna"> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/b/bb/Freiburg_2013_main2_Multiple_Targeting.png"> | ||
+ | <span> Multiple targeting </span> | ||
+ | </li> | ||
+ | </a> | ||
+ | <li style="margin-left: 40px; padding-bottom:8px;"><a href="https://2013.igem.org/Team:Freiburg/Project/method"> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/e/ef/UniBAss_freiburg_13.png" style="height:68px;"> | ||
+ | <span> uniBAss</span> | ||
+ | </li> | ||
+ | </a> | ||
+ | <li style="margin-bottom:-30px;"><a href="https://2013.igem.org/Team:Freiburg/Project/induction#light"> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/9/9a/Freiburg_2013_main2_Licht.png" style="height:57px;"> | ||
+ | <span> Light induction </span> | ||
+ | </li> | ||
+ | </a> | ||
+ | </ul> | ||
- | + | </div> | |
- | + | </div> | |
- | + | <img id="klammer_gross_rechts" src="https://static.igem.org/mediawiki/2013/8/82/Freiburg_2013_main2_Rahmen_gross_rechts.png"> | |
- | + | </td> | |
- | + | </tr> | |
+ | </table> | ||
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- | |||
- | + | <!-- ######################################################################################## | |
- | + | ||
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- | + | TABLE UNTEN | |
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- | + | ||
- | + | ######################################################################################## --> | |
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- | |||
- | < | + | <table id="table_viereck" style="margin-top:30px;"> |
- | + | ||
- | <!-- | + | <!-- ######################################################################################## |
- | + | ||
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+ | HIGHLIGHTS | ||
- | + | ######################################################################################## --> | |
- | |||
- | <div id=" | + | <tr> |
- | + | <td width="300px"> | |
- | <div style=" | + | <img id="klammer_klein_links" src="https://static.igem.org/mediawiki/2013/e/e0/Freiburg_2013_main2_Rahmen_gross_links.png"> |
+ | <div id="text-box3"> | ||
+ | <div id="text_gross" align="left"><a style="position:absolute; top:678px; left:60px; z-index:2" href="https://2013.igem.org/Team:Freiburg/Highlights"> Highlights </div> </a> | ||
+ | <p style="position:absolute; top:720px; left:60px" > All about our <br> project in one <br> slide show! </p> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/0/0e/Freiburg_2013_main2_Highlights5.png" height="190" style="position:absolute; top:614px; left:105px; z-index:1"> | ||
+ | </div> | ||
+ | <img id="klammer_klein_rechts" src="https://static.igem.org/mediawiki/2013/8/82/Freiburg_2013_main2_Rahmen_gross_rechts.png"> | ||
+ | </td> | ||
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- | + | <!-- ######################################################################################## | |
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- | + | TOOLKIT | |
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- | + | ######################################################################################## --> | |
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+ | <td width="300px"> | ||
+ | <img id="klammer_klein_links" src="https://static.igem.org/mediawiki/2013/e/e0/Freiburg_2013_main2_Rahmen_gross_links.png"> | ||
+ | <div id="text-box4"> | ||
+ | |||
+ | <div id="text_gross" align="left"> <a href="https://2013.igem.org/Team:Freiburg/Project/toolkit">Manual </a></div> | ||
+ | |||
+ | Use our Toolkit <br> to regulate your <br> genes! | ||
+ | <img src="https://static.igem.org/mediawiki/2013/5/5d/Freiburg_2013_main2_Toolkitnew.png" height="90" style="position:absolute; top:715px; left:464px"> | ||
+ | </div> | ||
+ | </div> | ||
+ | |||
+ | <img id="klammer_klein_rechts" src="https://static.igem.org/mediawiki/2013/8/82/Freiburg_2013_main2_Rahmen_gross_rechts.png"> | ||
+ | </td> | ||
- | |||
- | + | <!-- ######################################################################################## | |
- | + | ||
- | + | ||
- | + | HUMAN PRACTICE | |
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ######################################################################################## --> | |
+ | <td width="250px"> | ||
+ | <img id="klammer_klein_links" src="https://static.igem.org/mediawiki/2013/e/e0/Freiburg_2013_main2_Rahmen_gross_links.png"> | ||
+ | <div id="text-box5"> | ||
+ | |||
+ | <div id="text_gross" align="left"> <a style="position:absolute; top:678px; left:660px; z-index:2" href="https://2013.igem.org/Team:Freiburg/HumanPractice"> Human <br><br> Practice </a> </div> | ||
- | + | <img src="https://static.igem.org/mediawiki/2013/e/ee/Freibrug_startseite_Humanpractice.png" height="150" style="position:absolute; top:650px; left:655px; z-index:1"> | |
- | <img src="https://static.igem.org/mediawiki/2013/ | + | |
- | + | ||
+ | </div> | ||
+ | <img id="klammer_klein_rechts" src="https://static.igem.org/mediawiki/2013/8/82/Freiburg_2013_main2_Rahmen_gross_rechts.png"> | ||
+ | </td> | ||
+ | <!-- ######################################################################################## | ||
- | + | TEAM | |
- | + | ||
- | + | ||
- | + | ######################################################################################## --> | |
- | + | ||
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- | + | ||
+ | |||
+ | <td width="250px"> | ||
+ | <img id="klammer_klein_links" src="https://static.igem.org/mediawiki/2013/e/e0/Freiburg_2013_main2_Rahmen_gross_links.png"> | ||
+ | <div id="text-box6"> | ||
+ | |||
+ | <div id="text_gross" align="left"> <a style="position:absolute; top:678px; left:910px; z-index:2" href="https://2013.igem.org/Team:Freiburg/News"> News </a></div> | ||
+ | <p style="padding-top:10px;"> | ||
+ | Have a look at our achievements in Lyon & Boston! | ||
+ | </p> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/5/56/Best-foundational-advance-2013-freiburg.png" height="130" style="position:absolute; top:600px; left:980px; z-index:1"> | ||
+ | </div> | ||
</div> | </div> | ||
+ | <img id="klammer_klein_rechts" src="https://static.igem.org/mediawiki/2013/8/82/Freiburg_2013_main2_Rahmen_gross_rechts.png"> | ||
+ | </td> | ||
+ | </tr> | ||
+ | </table> | ||
+ | </div> | ||
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Latest revision as of 23:52, 9 April 2014
Our Team developed a universal toolkit, termed uniCAS, that enables customizable gene
regulation in mammalian cells. Therefore, we engineered the recently understood and highly promising
CRISPR/Cas9 system.
The regulation is based on the RNA-guided dCas9 protein, which allows specific targeting of DNA sequences. Our toolkit comprises not only a standardized dCas9 protein, but also different effector domains for efficient gene activation or repression. |
All about our |
Have a look at our achievements in Lyon & Boston! |