Team:INSA Toulouse

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       <h1 class="h1project">Project</h1>
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       <p>Since the beginning of Synthetic Biology, people aimed to transpose electronic devices into genetic constructions. In recent publications (<a href="http://www.ncbi.nlm.nih.gov/pubmed/23396014" style="color: #5a6060">Siuti and al. 2013</a>, <a href="http://www.sciencemag.org/content/340/6132/599.abstract" style="color: #5a6060">Bonnet and al. 2013</a>), a new design of one-way logical gates using Serine recombinases were described allowing to avoid reversibility of recombination and creating strong and robust genetic logical gates (AND, XOR, OR).  
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       <p>One major goal of Synthetic Biology is the transposition of electronic devices such as logic gates into genetic modules capables of circuit decisions. Recently (<a href="http://www.ncbi.nlm.nih.gov/pubmed/23396014" style="color: #5a6060">Siuti and al. 2013</a>, <a href="http://www.sciencemag.org/content/340/6132/599.abstract" style="color: #5a6060">Bonnet and al. 2013</a>), highly original logical gates utilizing Serine recombinases were described, avoiding reversibility of the genetic switch and thus creating strong and robust genetic logical gates (AND, XOR, OR).  
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The <i>E.calculus</i> project consists in creating a n-bits full-adder using those kinds of logical gates, which should be able to execute a 2 bits counting and also transmit any carry on the next step of the counting.</p>
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The <i>E. calculus</i> project exemplifies these genetic modules by creating a n-bits full-adder using the AND and XOR gates. The proposed design could perform a n bits counting with a carry. Our project could validate some of the original properties of these new genetic switches: irreversibility and accurate genetic transmission to the offspring</p>
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    <p><a href="https://2013.igem.org/Team:INSA_Toulouse/contenu/project/overview" style="color:white; text-decoration:none; weight:bold;">VIEW MORE</a></p>
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Revision as of 06:56, 27 September 2013

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Project

One major goal of Synthetic Biology is the transposition of electronic devices such as logic gates into genetic modules capables of circuit decisions. Recently (Siuti and al. 2013, Bonnet and al. 2013), highly original logical gates utilizing Serine recombinases were described, avoiding reversibility of the genetic switch and thus creating strong and robust genetic logical gates (AND, XOR, OR).
The E. calculus project exemplifies these genetic modules by creating a n-bits full-adder using the AND and XOR gates. The proposed design could perform a n bits counting with a carry. Our project could validate some of the original properties of these new genetic switches: irreversibility and accurate genetic transmission to the offspring