Team:Freiburg/main2

From 2013.igem.org

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   Our Team developed a universal toolkit,  termed uniCAS, that enables customizable gene     
   Our Team developed a universal toolkit,  termed uniCAS, that enables customizable gene     
     regulation in mammalian cells.  Therefore, we engineered the recently discovered and highly promising   
     regulation in mammalian cells.  Therefore, we engineered the recently discovered and highly promising   
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Revision as of 11:40, 27 September 2013


Abstract

Our Team developed a universal toolkit, termed uniCAS, that enables customizable gene regulation in mammalian cells. Therefore, we engineered the recently discovered and highly promising CRISPR/Cas9 system. The regulation is based on the RNA-guided Cas9 protein, which allows targeting of specific DNA sequences. Our toolkit comprises not only a standardized Cas9 protein, but also different effector domains for efficient gene activation or repression.

Our Project

  • Activation
  • Repression
  • Epigenetics
  • uniBAss
  • Multiple targeting
  • Light switch