Our project focuses on developing a novel treatment for <a href="https://2013.igem.org/Team:Evry/Project_diseases">hematological disorders</a>  caused by an iron overload <a href="https://2013.igem.org/Team:Evry/Project_metabolism</a>, such as hemochromatosis and thalassemia. These autosomal recessive disorders have symptoms including cirrhosis, arthritis, and heart failure, which result from overabsorption of iron from the duodenum. Although these are among the most common heritable diseases, treatment options are limited. Even today patients are mostly treated by frequent bloodletting, which many people cannot support. The aim of our project is to combat these diseases at the source by developing a therapy that prevents the intestinal absorption of iron.