Team:Evry/Modeltr1

From 2013.igem.org

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<h2>Introduction</h2>
<h2>Introduction</h2>
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At the beginning of the project, we must explore iron metabolism of a human. This model is the result of this exploration. So, we make a model of a healthy person.
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In the very beginning of the project, we focused on the duodenum and the iron absorbed by it. In order to determine if a flush treatment strategy was viable, we first had to model the behaviour of the duodenum regarding iron absorption.
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<h2>Observations</h2>
<h2>Observations</h2>
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60% of iron absorption takes place in the duodenum, the last 40% in the jejunum.Duodenum is located on the upper intestines, just after the stomach, and is usually 300mm long. Naturaly, the middle is the duodenum.
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60% of iron absorption takes place in the duodenum, the last 40% in the jejunum. The duodenum is located at the upper intestines, right after the stomach, and is usually 300mm long.
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     <b>Figure 1 : </b> Overview of the iron regulation system in human body.
     <b>Figure 1 : </b> Overview of the iron regulation system in human body.
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A healthy person absorbed 10% of the iron uptake of a day (2 mg), while a sick person could absorb between 50% and 100% of the iron uptake in one day ([1]).
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A healthy person absorbs about 10% of the daily iron uptake(2 mg), while a hemochromatosis person's absorption varies between 50% and 100% of the daily iron uptake<sup>[1]</sup>.
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Revision as of 09:21, 26 October 2013

Iron coli project

Disease model

Introduction

In the very beginning of the project, we focused on the duodenum and the iron absorbed by it. In order to determine if a flush treatment strategy was viable, we first had to model the behaviour of the duodenum regarding iron absorption.

Observations

60% of iron absorption takes place in the duodenum, the last 40% in the jejunum. The duodenum is located at the upper intestines, right after the stomach, and is usually 300mm long.

Absorption
Figure 1 : Overview of the iron regulation system in human body.

A healthy person absorbs about 10% of the daily iron uptake(2 mg), while a hemochromatosis person's absorption varies between 50% and 100% of the daily iron uptake[1].

Goals

This model is the first step for a sick person with treatment model . So, we want to have a realistic base for the final model.

Assumptions

  • Constant iron flow
  • Homogeneous fluid
  • The patient ingests 20mg of iron per day (Guideline Daily Amounts)

Materials and methods

The duodenum is a cylindrique pipe throw by a homogeneous fluid. So, we three step in the model: the filling of duodenum, steady state step and the emptying. This model have two state variable : iron disolved in the middle (S) and iron absorbed (A).
We considere a constant iron pulse every second arrive in the duodenum. S have a linear composant Sp who represent the pulses. We have the emptying compopsant and finally the absorption composant. We assume a linear absorption and a negative feedback regulation for A. Finally :

α s-1 Duodenum absorption rate
v m/s Chyme's flow average speed
L m Duodenum length
Sp mol/s Iron pulse
Parameters fixing :
We have

Results

Absorption
Figure 2 : Iron in the middle and absorbed in the duodenum of a Healthy person.

Absorption
Figure 3 : Iron in the middle and absorbed in the duodenum of a sick person.

Conclusion

Models and scripts

References:

  1. Physiol Rev 93: 1721–1741, 2013 doi:10.1152/physrev.00008.2013 - Tomas Ganz "SYSTEMIC IRON HOMEOSTASIS"

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