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Team:TU-Eindhoven
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Welcome to the homepage of the 2013 iGEM team of the Eindhoven University of Technology. | Welcome to the homepage of the 2013 iGEM team of the Eindhoven University of Technology. | ||
{{:Team:TU-Eindhoven/Template:LeadEnd}} | {{:Team:TU-Eindhoven/Template:LeadEnd}} | ||
| - | Within our project we aim to focus on a relatively new form of {{:Team:TU-Eindhoven/Template:Tooltip | text=MRI | tooltip=Magnetic Resonance Imaging }}: {{:Team:TU-Eindhoven/Template:Tooltip | text=CEST | tooltip=Chemical Exchange Saturation Transfer }} imaging. Within CEST imaging proteins containing hydrogen atoms can be used to create the same quality of images as when heavy metals are used. We | + | Within our project we aim to focus on a relatively new form of {{:Team:TU-Eindhoven/Template:Tooltip | text=MRI | tooltip=Magnetic Resonance Imaging }}: {{:Team:TU-Eindhoven/Template:Tooltip | text=CEST | tooltip=Chemical Exchange Saturation Transfer }} imaging. Within CEST imaging proteins containing hydrogen atoms can be used to create the same quality of images as when heavy metals are used. We will E. coli K-12 to produce these proteins once it enters the body, allowing the bacteria to be our delivery system and production factory. Unique to our process will be the injection of the protein producing bacteria into the patient, as well as the tumour targeting element of the bacteria. Tumours present a {{:Team:TU-Eindhoven/Template:Tooltip | text=hypoxic | tooltip=Low oxygen saturation }} environment, allowing them to be targetted by our bacteria. These hypoxic conditions will furthermore be the trigger for the production of our CEST proteins. This will ensure contrast is created where tumours are present, and also provides a good means of tumour targeting for drug delivery in the future. |
{{:Team:TU-Eindhoven/Template:Quote | text=We will attempt to create bacteria that can visualize tumors<br />on a MRI scan, without the use of heavy metals. | by=Mission Statement of the TU/e iGEM 2013 Team | position=right }} | {{:Team:TU-Eindhoven/Template:Quote | text=We will attempt to create bacteria that can visualize tumors<br />on a MRI scan, without the use of heavy metals. | by=Mission Statement of the TU/e iGEM 2013 Team | position=right }} | ||
Revision as of 17:12, 28 July 2013
Welcome to the homepage of the 2013 iGEM team of the Eindhoven University of Technology.
Within our project we aim to focus on a relatively new form of MRI: CEST imaging. Within CEST imaging proteins containing hydrogen atoms can be used to create the same quality of images as when heavy metals are used. We will E. coli K-12 to produce these proteins once it enters the body, allowing the bacteria to be our delivery system and production factory. Unique to our process will be the injection of the protein producing bacteria into the patient, as well as the tumour targeting element of the bacteria. Tumours present a hypoxic environment, allowing them to be targetted by our bacteria. These hypoxic conditions will furthermore be the trigger for the production of our CEST proteins. This will ensure contrast is created where tumours are present, and also provides a good means of tumour targeting for drug delivery in the future.We will attempt to create bacteria that can visualize tumors
Mission Statement of the TU/e iGEM 2013 Team
on a MRI scan, without the use of heavy metals.
About Us
We are the 2013 iGEM team from Eindhoven, the Netherlands.
Learn more...
Wetlab
Take a look at the results of the broad range of experiments performed this year.
Learn more...
Drylab
Various simulations were carried out to support the wetlab experiments.
Learn more...
