Team:Freiburg

From 2013.igem.org

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<p id="h1"> Gene Regulation – Multiple Targets – Activation – Optogenetics – Repression – Inducibility – Epigenetics
 
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<p id="fett">Just imagine there was a tool that combined all these aspects of lab work. A tool, that was able to rule several genes at once; a tool that allowed highly specific gene modulation via stimulus induction; a tool that would be a new approach to gene regulation. </p>
 
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<p>This year’s Freiburg iGEM Team uses the prokaryotic CRISPR/Cas system to enable multiple endogenous gene regulation with minimal effort. The regulation is based on a protein-RNA-DNA interaction. Customizable RNAs function as a guide for our protein in order to target specific DNA sequences. By fusing effector domains to this protein, we aim at developing a tool for multiple and inducible gene activation and repression. Despite the system's prokaryotic origin, gene target sequences are adjustable for various organisms, offering a broad application variety of our tool. Due to its great potential, the CRISPR/Cas system has become of increasing importance in current research and can be implemented in a number of novel and interesting applications, such as gene therapy or tissue engineering. </p>
 
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{{Template:Sponsors:Freiburg2013 Sponsors}}
 

Revision as of 13:14, 28 August 2013

Retrieved from "http://2013.igem.org/Team:Freiburg"