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Team:HZAU-China/Home
From 2013.igem.org
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| - | <p style="font-family:Arial,Helvetica,sans-serif;font-size:30px;font-color:#fff;text-align:center;padding:20px; margin:0px;"><a href=""></a></p> | + | <p style="font-family:Arial,Helvetica,sans-serif;font-size:30px;font-color:#fff;text-align:center;padding:20px; margin:0px;"><a href="">Yersinia pestis and flea</a></p> |
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| - | <p style="font-family:Arial,Helvetica,sans-serif;font-size:17px;font-color:#000;text-align:justify;padding:10px; margin:0px;"> </p> | + | <p style="font-family:Arial,Helvetica,sans-serif;font-size:17px;font-color:#000;text-align:justify;padding:10px; margin:0px;">Y.pestis can form biofilms to colonize proventricular of flea. Blocked fleas can transfer Yersinia pestis to host. The mechanism has been widely researched. Although it is too early for us to release cleaning flea, we do spend much time in thinking of this mechanism. You can find the details of this interesting mechanism in this section.</p> |
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| - | <p style="font-family:Arial,Helvetica,sans-serif;font-size:30px;font-color:#fff;text-align:center;padding:20px; margin:0px;"><a href=""></a></p> | + | <p style="font-family:Arial,Helvetica,sans-serif;font-size:30px;font-color:#fff;text-align:center;padding:20px; margin:0px;"><a href="">Bacillus subtilis as vector of vaccine.</a></p> |
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| - | <p style="font-family:Arial,Helvetica,sans-serif;font-size:17px;font-color:#000;text-align:justify;padding:10px; margin:0px;"> </p> | + | <p style="font-family:Arial,Helvetica,sans-serif;font-size:17px;font-color:#000;text-align:justify;padding:10px; margin:0px;">Bacillus subtilis have a long history of industrial and biotechnological application. It has been explored as a vector for the expression of foreign proteins with immunological activities. Both of endospores and modified bacteria strain can be use as live carriers of antigen.</p> |
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| - | <p style="font-family:Arial,Helvetica,sans-serif;font-size:30px;font-color:#fff;text-align:center;padding:20px; margin:0px;"><a href=""></a></p> | + | <p style="font-family:Arial,Helvetica,sans-serif;font-size:30px;font-color:#fff;text-align:center;padding:20px; margin:0px;"><a href="">Cellular automata</a></p> |
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| - | <p style="font-family:Arial,Helvetica,sans-serif;font-size:17px;font-color:#000;text-align:justify;padding:10px; margin:0px;"> </p> | + | <p style="font-family:Arial,Helvetica,sans-serif;font-size:17px;font-color:#000;text-align:justify;padding:10px; margin:0px;">In order to know whether safe moving vaccine factory can reach 70% vaccination coverage of dogs, Cellular automata model has been used to simulate the spreading of immunity. </p> |
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| - | <p style="font-family:Arial,Helvetica,sans-serif;font-size:30px;font-color:#fff;text-align:center;padding:20px; margin:0px;"><a href=""></a></p> | + | <p style="font-family:Arial,Helvetica,sans-serif;font-size:30px;font-color:#fff;text-align:center;padding:20px; margin:0px;"><a href="">Judging form</a></p> |
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| - | <p style="font-family:Arial,Helvetica,sans-serif;font-size:17px;font-color:#000;text-align:justify;padding:10px; margin:0px;"> </p> | + | <p style="font-family:Arial,Helvetica,sans-serif;font-size:17px;font-color:#000;text-align:justify;padding:10px; margin:0px;">This year is the first time we attend iGEM. And we apply to attend this competition on 27/04/2013. It must be a big challenge for anyone to finish iGEM in just six month. We finish this hard work with trial and error. From our judging form, you can know what we have done in six month. </p> |
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Revision as of 06:02, 27 September 2013
PROJECT: Safe Moving Vaccine Factory
ABSTRACT
Our idea comes from Yersinia pestis and fleas. We make use of fleas as our moving injector. When flea feed blood from dogs, our vaccine vector Bacillus subtilis will be regurgitated into blood and successfully transferred to mammalian host. Bacillus subtilis can express antigens which can stimulate the immunity of dogs. Meanwhile, endogenous or exogenous expression of "Antimicrobial Peptides" by B. subtilis can kill Yersinia pestis in fleas. In this way we achieved a safe moving vaccine factory.
