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Team:Evry/Modeltr1
From 2013.igem.org
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<img src="https://static.igem.org/mediawiki/2013/8/82/Healthyeq.png" width=15% /><br/> | <img src="https://static.igem.org/mediawiki/2013/8/82/Healthyeq.png" width=15% /><br/> | ||
| + | |||
| + | <table width="100%" border="1"> | ||
| + | <tr width="100%"> | ||
| + | <th>Name</th> | ||
| + | <th>Unit</th> | ||
| + | <th>Description</th> | ||
| + | </tr> | ||
| + | <tr width="100%"> | ||
| + | <td>alpha</td> | ||
| + | <td>s-1</td> | ||
| + | <td>Duodenum absorption rate</td> | ||
| + | </tr> | ||
| + | <tr width="100%"> | ||
| + | <td>v</td> | ||
| + | <td>m/s</td> | ||
| + | <td>Chyme's flow average speed</td> | ||
| + | </tr> | ||
| + | <tr width="100%"> | ||
| + | <td>L</td> | ||
| + | <td>m</td> | ||
| + | <td>Duodenum length</td> | ||
| + | </tr> | ||
| + | <tr width="100%"> | ||
| + | <td>Sp</td> | ||
| + | <td>mol/s</td> | ||
| + | <td>Iron pulse</td> | ||
| + | </tr> | ||
| + | </table> | ||
| + | |||
| + | <br>Parameters fixing :</br> | ||
| + | |||
| + | We have | ||
</p> | </p> | ||
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<h2>Results</h2> | <h2>Results</h2> | ||
<p> | <p> | ||
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<div class="captionedPicture" style="width:100%;"> | <div class="captionedPicture" style="width:100%;"> | ||
<a title="Absorption" href="https://static.igem.org/mediawiki/2013/b/b7/Duohealth.png"> | <a title="Absorption" href="https://static.igem.org/mediawiki/2013/b/b7/Duohealth.png"> | ||
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</a> | </a> | ||
<div class="caption"> | <div class="caption"> | ||
| - | <b>Figure | + | <b>Figure 2 : </b> Iron in the middle and absorbed in the duodenum of a Healthy person. |
</div> | </div> | ||
</div> | </div> | ||
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</a> | </a> | ||
<div class="caption"> | <div class="caption"> | ||
| - | <b>Figure | + | <b>Figure 3 : </b> Iron in the middle and absorbed in the duodenum of a sick person. |
</div> | </div> | ||
</div> | </div> | ||
Revision as of 17:34, 23 October 2013
Disease model
Introduction
At the beginning of the project, we must explore iron metabolism of a human. This model is the result of this exploration. So, we make a model of a healthy person.
Observations
60% of iron absorption takes place in the duodenum, the last 40% in the jejunum.Duodenum is located on the upper intestines, just after the stomach, and is usually 300mm long. Naturaly, the middle is the duodenum.
A healthy person absorbed 10% of the iron uptake of a day (2 mg), while a sick person could absorb between 50% and 100% of the iron uptake in one day ([1]).
Goals
This model is the first step for a sick person with treatment model . So, we want to have a realistic base for the final model.
Assumptions
- Constant iron flow
- Homogeneous fluid
- The patient ingests 20mg of iron per day (Guideline Daily Amounts)
Materials and methods
The duodenum is a cylindrique pipe throw by a homogeneous fluid. So, we three step in the model: the filling of duodenum, steady state step and the emptying.
This model have two state variable : iron disolved in the middle (S) and iron absorbed (A).
We considere a constant iron pulse every second arrive in the duodenum. S have a linear composant Sp who represent the pulses. We have the emptying compopsant and finally the absorption composant.
We assume a linear absorption and a negative feedback regulation for A.
Finally :
| Name | Unit | Description |
|---|---|---|
| alpha | s-1 | Duodenum absorption rate |
| v | m/s | Chyme's flow average speed |
| L | m | Duodenum length |
| Sp | mol/s | Iron pulse |
Parameters fixing : We have
Results
Conclusion
Models and scripts
References:
- Physiol Rev 93: 1721–1741, 2013 doi:10.1152/physrev.00008.2013 - Tomas Ganz "SYSTEMIC IRON HOMEOSTASIS"
