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Team:Evry/Modeltr1
From 2013.igem.org
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| - | A healthy person absorbs about 10% of the daily iron uptake(2 mg), while a hemochromatosis person's absorption varies between 50% and 100% of the daily iron uptake<sup>[1]</sup>. | + | A healthy person absorbs about 10% of the daily iron uptake(2 mg), while a hemochromatosis person's absorption varies between 50% and 100% of the daily iron uptake<sup><a href="#Ref">[1]</a></sup>. |
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<a id="Assumptions"></a> | <a id="Assumptions"></a> | ||
<h2>Assumptions</h2> | <h2>Assumptions</h2> | ||
| - | |||
<ul> | <ul> | ||
| + | <li>Our bacteria don't settle in the duodenum</li> | ||
| + | <li>No regulation in the patient's iron absorption</li> | ||
<li>Constant iron flow</li> | <li>Constant iron flow</li> | ||
<li>Homogeneous fluid</li> | <li>Homogeneous fluid</li> | ||
| + | <li>The bacterial quantity is constant</li> | ||
| + | <li>The bacterial natural absorption is insignificant compared to the chelation</li> | ||
<li>The patient ingests 20mg of iron per day (Guideline Daily Amounts)</li> | <li>The patient ingests 20mg of iron per day (Guideline Daily Amounts)</li> | ||
</ul> | </ul> | ||
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<div id="citation_box"> | <div id="citation_box"> | ||
| + | <a id="Ref"></a> | ||
<p id="references">References:</p> | <p id="references">References:</p> | ||
<ol> | <ol> | ||
Revision as of 09:25, 26 October 2013
Disease model
Introduction
In the very beginning of the project, we focused on the duodenum and the iron absorbed by it. In order to determine if a flush treatment strategy was viable, we first had to model the behaviour of the duodenum regarding iron absorption.
Observations
60% of iron absorption takes place in the duodenum, the last 40% in the jejunum. The duodenum is located at the upper intestines, right after the stomach, and is usually 300mm long.
A healthy person absorbs about 10% of the daily iron uptake(2 mg), while a hemochromatosis person's absorption varies between 50% and 100% of the daily iron uptake[1].
Goals
This model is the first step for a sick person with treatment model . So, we want to have a realistic base for the final model.
Assumptions
- Our bacteria don't settle in the duodenum
- No regulation in the patient's iron absorption
- Constant iron flow
- Homogeneous fluid
- The bacterial quantity is constant
- The bacterial natural absorption is insignificant compared to the chelation
- The patient ingests 20mg of iron per day (Guideline Daily Amounts)
Materials and methods
The duodenum is a cylindrique pipe throw by a homogeneous fluid. So, we three step in the model: the filling of duodenum, steady state step and the emptying.
This model have two state variable : iron disolved in the middle (S) and iron absorbed (A).
We considere a constant iron pulse every second arrive in the duodenum. S have a linear composant Sp who represent the pulses. We have the emptying compopsant and finally the absorption composant.
We assume a linear absorption and a negative feedback regulation for A.
Finally :
| α | s-1 | Duodenum absorption rate |
| v | m/s | Chyme's flow average speed |
| L | m | Duodenum length |
| Sp | mol/s | Iron pulse |
We have
Results
Conclusion
Models and scripts
