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Team:NYMU-Taipei/Project/Overview
From 2013.igem.org
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Backgroud:
Honey bee is a social insect and can be divided into several classes – queens, drones, and workers, which can further be classified into field bee (which is responsible for getting honey from the nature) and house bee (which is responsible for cleaning hives). However, a single bee (especially field bee) may fall ill to CCD when it intakes water or food contaminated by Nosema ceranae spores. What’s worse, CCD may in turn spread to other bees through exchanging substances via mouthparts or feeding food to sacbroods.
After getting into bees’ midgut, Nosema spores will germinate, elongate its polarfilament, and pierce into midgut epithelial cells to transmit its genetic material. After finishing several life cycles, the infected epithelial cells will burst, leading to the spread of Nosema spores to nearby epithelial cells.
The life cycle of Nosema Ceranae:
The spores of Nosema ceranae:
The method is let bees ingest the encapsulated Bee. coli, which is suspended in sugar solution and will proliferate in bees’ midgut to build up bees’ immunity.
