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Team:UC Davis
From 2013.igem.org
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Project BackgroundLearn about how we combine riboswitches and TALs into robust orthogonal mechanisms for inducible repression. |
ResultsCheck out the results of our experiments with RiboTALs. |
Human PracticesTake a look at how we designed a new database for better raw data characterization of Biobricks. |
Judging CriteriaHere's the criteria that we met for this year's team. |
Welcome
Welcome to the 2013 UC Davis iGEM Wiki!
We have a created a novel class of transcription factors known as RiboTALs. We sought to address the constraints placed on circuit design by the limited number of well characterized promoters at our disposal, and their respective transcription factors. Our device generates Transcriptional Activator-Like (TAL) effectors which can be engineered to bind to and repress any sequence of interest. The production of these repressor proteins is controlled by riboswitches, and thus inherit the potential of riboswitches to respond to any inducer molecule due to their engineerable and modular aptamer binding domains.
We also created a Biobrick Characterization Data Depot for more thorough characterization of the Registry's Biobricks. We hope that future iGEM teams may use this database to better understand a Biobrick's functionality.
