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Team:Evry/Modeltr1
From 2013.igem.org
Disease model
Introduction
At the beginning of the project, we must explore iron metabolism of a human. This model is the result of this exploration. So, we make a model of a healthy person.
Observations
The most of absorbed iron is in the duodenum. Naturaly, the middle is the duodenum.
The duodenum is the first part of the intestines. It is located right after the stomach, and is usually 300mm long.
Figure 1 : Overview of the iron regulation system in human body.
A healthy person absorbed 10% of the iron uptake of a day, while a sick person could absorb between 50% and 100% of the iron uptake in one day ([1]).
Goals
This model is the base for a sick person with treatment model . So, we want to have a realistic base for the final model.
Assumptions
- Constant iron flow
- Homogeneous fluid
- The patient ingests 20mg of iron per day (Guideline Daily Amounts)
Materials and methods
Results
Figure 1 : Iron in the middle and absorbed in the duodenum of a Healthy person.
Figure 2 : Iron in the middle and absorbed in the duodenum of a sick person.
Conclusion
Models and scripts
References:
- Physiol Rev 93: 1721–1741, 2013 doi:10.1152/physrev.00008.2013 - Tomas Ganz "SYSTEMIC IRON HOMEOSTASIS"
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