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Team:TU-Delft/NovelPeptides
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only the records that target both E.coli and S.aureus were taken into account. The acquired records were seperated into 4 classes based on the MIC values: | only the records that target both E.coli and S.aureus were taken into account. The acquired records were seperated into 4 classes based on the MIC values: | ||
</p> | </p> | ||
| + | <br> | ||
<ul style="list-style-type: circle"> | <ul style="list-style-type: circle"> | ||
| - | <li>1st class: Toxic for both S.aureus and E.coli </li> | + | <li><b>1st class:</b> Toxic for both S.aureus and E.coli </li> |
| + | <li><b>2nd class:</b> Toxic for S.aureus but not for E.coli </li> | ||
| + | <li><b>3rd class:</b> Toxic for E.coli but not for S.aureus </li> | ||
| + | <li><b>4th class:</b> Non Toxic for both E.coli and S.aureus </li> | ||
</ul> | </ul> | ||
Revision as of 09:10, 11 September 2013
Novel Peptides
The antimicrobial peptide(AMPs) field is growing rapidly in response to the demand for novel antimicrobial agents. In particular AMPs are promising candidates in the fight against antibiotic-resistant pathogents due to their low toxicity, and broad range of activity. Antimicrobial peptides are generally between 12 and 50 amino acids long. These peptides include two or more positively charged residues provided by arginine, lysine or, in acidic environments, histidine, and a large proportion of hydrophobic residues.
Due to the fact that AMPs constitute a current research area, both the knowledge and the experimentally validated data are rapidly increasing.It was decided to use these data in order to create novel peptides which will be high toxic for S.aureus but low toxic for E.coli. The method that was developed is described in the following sections.
Data and Feature extraction
The necessary data were acquired from the CAMP: Collection of Anti-Microbial Peptides Database. The database contains 3789 records with MIC values but only the records that target both E.coli and S.aureus were taken into account. The acquired records were seperated into 4 classes based on the MIC values:
- 1st class: Toxic for both S.aureus and E.coli
- 2nd class: Toxic for S.aureus but not for E.coli
- 3rd class: Toxic for E.coli but not for S.aureus
- 4th class: Non Toxic for both E.coli and S.aureus
