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Team:TU-Delft/Peptides
From 2013.igem.org
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interact with the opposite charges present on the membrane thus boring a hole through the membrane subsequently lysing the cell.Unlike, antibiotics they do not interfere in the genetic, transcriptional or translational machinery of the cells. | interact with the opposite charges present on the membrane thus boring a hole through the membrane subsequently lysing the cell.Unlike, antibiotics they do not interfere in the genetic, transcriptional or translational machinery of the cells. | ||
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| - | + | We chose 3 AMP's that are mostly produced in the skins of toads and frogs. They are magainin from <i>Xenopus laevis</i> , signiferin from <i>Crinia signifera</i> and maximin-H5 from <i>Bombina maxima</li>. The reasons for choosing these AMP's could be attributed to their target specific nature, charge and length of peptides. They do not affect humans, which makes them a suitable candidate as pharmaceuticals. | |
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Revision as of 11:28, 12 September 2013
Peptides
The era of antibiotics are now outdated as the microorganisms started gaining new resistance mechanism to evade the effects of antibiotics. Nowadays more and more researches are focused towards new antimicrobial that can be more effective against these pathogens.
The antimicrobial peptides (AMP's), natural or de-novo are becoming more popular due to their potential to kill or restrict the growth of microorganisms. They form a part of chemical defense against predators. All organisms, including higher order eukaryotes have some antimicrobial peptides that acts against specific strains of microorganisms.They are usually charged and
interact with the opposite charges present on the membrane thus boring a hole through the membrane subsequently lysing the cell.Unlike, antibiotics they do not interfere in the genetic, transcriptional or translational machinery of the cells.
We chose 3 AMP's that are mostly produced in the skins of toads and frogs. They are magainin from Xenopus laevis , signiferin from Crinia signifera and maximin-H5 from Bombina maxima. The reasons for choosing these AMP's could be attributed to their target specific nature, charge and length of peptides. They do not affect humans, which makes them a suitable candidate as pharmaceuticals.
