Team:Freiburg/Highlights/2
From 2013.igem.org
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+ | 6 opportunities with our uniCAS toolkit | ||
+ | </p> | ||
+ | <p> | ||
+ | We provide 3 different effectors, 2 methods & 1 effector controller! Using our toolkit it's possible to efficiently activate or repress genes. We also provide devices for effector controling by light. Use our custom-tailored <a id="link" href="https://2013.igem.org/Team:Freiburg/Project/toolkit"> Manual Tool </a> to generate your individual manual for your needs of gene regulation. Further it's possible to target not only one, but multiple genes of interest! And we established <a id="link" href="">uniBAss</a> - our universal Binding Assay. Best of all: It's open source and in iGEM standard! | ||
+ | </p> | ||
+ | </div> | ||
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+ | <div style="text-align: center;"> | ||
+ | <EMBED HEIGHT=460 WIDTH=450 TYPE="video/quicktime" | ||
+ | PLUGINSPAGE="http://www.apple.com/quicktime/download/" | ||
+ | SRC="https://static.igem.org/mediawiki/2013/b/be/Cas_binding.mov" | ||
+ | AUTOPLAY="false"/></OBJECT> | ||
+ | </div> | ||
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+ | <div class="slide-right-col"> | ||
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+ | <p id="headline"> | ||
+ | dCas9 - The Heart of our toolkit | ||
+ | </p> | ||
+ | <p> | ||
+ | We started by mutating the DNA cleavage site in the Cas9 protein and generated a sequence specific DNA binding protein that is relying on a protein-RNA-DNA interaction. We are now able to influence the DNA binding locus and can direct the protein to requested DNA targets.<br> | ||
+ | This is the heart of our toolkit. A protein that allows multiple and sequence specifid DNA binding.<br><br> | ||
+ | For simple and flexible regulation we do need now effectors, that can be fused to the protein.<br> | ||
+ | |||
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+ | <!--simple DNA binding protein is the foundation of our project and all effectors used in this toolkit are fused to it.--> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/f/f4/Dna_freiburg_13_ruppel_die_katz.png" style="width:650px; margin-top:110px; margin-left:-106px;"> | ||
+ | </div> | ||
+ | <div class=clear></div> | ||
+ | </div> | ||
+ | </li> | ||
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+ | <div class="frontpage-slide"> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/1/18/Picture7.png"> | ||
+ | <div class="slide-right-col"> | ||
+ | <div class="slide-heading"> | ||
+ | The Toolbox | ||
+ | </div> | ||
+ | <p><a href="http://"> | ||
+ | Click here to read more</a> about what the toolbox is and how you can use it.</p> | ||
+ | </div> | ||
+ | <div class=clear></div> | ||
+ | </div> | ||
+ | </li> | ||
+ | <li> | ||
+ | <div class="frontpage-slide"> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/1/18/Picture7.png"> | ||
+ | <div class="slide-right-col"> | ||
+ | <div class="slide-heading"> | ||
+ | The Toolbox | ||
+ | </div> | ||
+ | <p><a href="http://"> | ||
+ | Click here to read more</a> about what the toolbox is and how you can use it.</p> | ||
+ | </div> | ||
+ | <div class=clear></div> | ||
+ | </div> | ||
+ | </li> | ||
+ | <li> | ||
+ | <div class="frontpage-slide"> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/1/18/Picture7.png"> | ||
+ | <div class="slide-right-col"> | ||
+ | <div class="slide-heading"> | ||
+ | The Toolbox | ||
+ | </div> | ||
+ | <p><a href="http://"> | ||
+ | Click here to read more</a> about what the toolbox is and how you can use it.</p> | ||
+ | </div> | ||
+ | <div class=clear></div> | ||
+ | </div> | ||
+ | </li> | ||
+ | <li> | ||
+ | <div class="frontpage-slide"> | ||
+ | <img src="https://static.igem.org/mediawiki/2013/1/18/Picture7.png"> | ||
+ | <div class="slide-right-col"> | ||
+ | <div class="slide-heading"> | ||
+ | The Toolbox | ||
+ | </div> | ||
+ | <p><a href="http://"> | ||
+ | Click here to read more</a> about what the toolbox is and how you can use it.</p> | ||
+ | </div> | ||
+ | <div class=clear></div> | ||
+ | </div> | ||
+ | </li> | ||
+ | <li> | ||
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Revision as of 11:12, 4 October 2013
HIGHLIGHTS